2-(3-Chloro-4-fluoroanilino)acetohydrazide

Base Information

• Chemical Name: 2-(3-Chloro-4-fluoroanilino)acetohydrazide
• CAS No.: 2370-44-7
• Molecular Formula: C8H9 Cl F N3 O
• Molecular Weight: 217.63
• Hs Code.: 2928000090
• NSC Number: 190323
• DSSTox Substance ID: DTXSID50307172
• Wikidata: Q82054529
• Mol file: 2370-44-7.mol

Synonyms:2370-44-7;2-(3-chloro-4-fluoroanilino)acetohydrazide;2-((3-Chloro-4-fluorophenyl)amino)acetohydrazide;2-[(3-chloro-4-fluorophenyl)amino]acetohydrazide;N-(3-Chloro-4-fluorophenyl)glycinehydrazide;NSC190323;SCHEMBL2319841;DTXSID50307172;JS-045C;MFCD03788387;AKOS005073022;NSC-190323;SB86065;CS-0328261;FT-0681113;A816855;J-505218;2-[(3-chloranyl-4-fluoranyl-phenyl)amino]ethanehydrazide

Chemical Property of 2-(3-Chloro-4-fluoroanilino)acetohydrazide

Chemical Property:

• Vapor Pressure: 3.79E-09mmHg at 25°C
• Melting Point: 99-100oC
• Boiling Point: 473.9°C at 760 mmHg
• Flash Point: 240.4°C
• PSA: 67.15000
• Density: 1.439g/cm³
• LogP: 2.04510
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 217.0418178
• Heavy Atom Count: 14
• Complexity: 205

Purity/Quality:

97% ^*data from raw suppliers

2-(3-chloro-4-fluoroanilino)acetohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1NCC(=O)NN)Cl)F

Technology Process of 2-(3-Chloro-4-fluoroanilino)acetohydrazide

There total 4 articles about 2-(3-Chloro-4-fluoroanilino)acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-((3-chloro-4-fluorophenyl)amino)acetate (2344-98-1) → 4-fluoro-3-chlorophenylaminoethanehydrazide (2370-44-7)

Guidance literature:

With hydrazine hydrate; for 0.00833333h; Microwave irradiation;

DOI:10.1111/cbdd.12118

Reference yield:

3-chloro-4-fluorophenylamine (367-21-5) → 4-fluoro-3-chlorophenylaminoethanehydrazide (2370-44-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate / water / 3 h / 90 °C

2: hydrazine hydrate / 0.01 h / Microwave irradiation

With hydrazine hydrate; sodium acetate; In water;

DOI:10.1111/cbdd.12118

Reference yield:

(3-Chloro-4-fluoro-phenylamino)-acetic acid → 4-fluoro-3-chlorophenylaminoethanehydrazide (2370-44-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 2 h / Reflux

2: hydrazine hydrate / ethanol / Reflux

With sulfuric acid; hydrazine hydrate; In ethanol;

DOI:10.2174/1570180816666181113110033

upstream raw materials:

3-chloro-4-fluorophenylamine

ethyl 2-((3-chloro-4-fluorophenyl)amino)acetate

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