7-Iodooxindole

Base Information

• Chemical Name: 7-Iodooxindole
• CAS No.: 31676-49-0
• Molecular Formula: C8H6INO
• Molecular Weight: 259.04
• DSSTox Substance ID: DTXSID101299073
• Nikkaji Number: J1.690.200D
• Mol file: 31676-49-0.mol

Synonyms:7-iodooxindole;31676-49-0;1,3-Dihydro-7-iodo-2H-indol-2-one;7-?Iodooxindole;7-Iodo-2-indolinone;7-iodo-1,3-dihydroindol-2-one;SCHEMBL19753764;DTXSID101299073;MFCD09835634;7-iodo-2,3-dihydro-1H-indol-2-one;CS-0109537;FT-0709699;D76870

Chemical Property of 7-Iodooxindole

Chemical Property:

• Melting Point: 208-209℃
• PSA: 29.10000
• LogP: 1.92380
• Sensitive.: Light Sensitive
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 258.94941
• Heavy Atom Count: 11
• Complexity: 183

Purity/Quality:

98%,99%, ^*data from raw suppliers

7-Iodo-1,3-dihydro-2H-indol-2-one AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1C2=C(C(=CC=C2)I)NC1=O

Technology Process of 7-Iodooxindole

There total 5 articles about 7-Iodooxindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

7-iodoisatin (20780-78-3) → 7-iodooxindole (31676-49-0)

Guidance literature:

7-iodoisatin; With hydrazine hydrate; at 125 ℃; for 1h;

With hydrogenchloride; at 60 ℃; for 2h;

DOI:10.1002/1521-3773(20010518)40:10<1967::AID-ANIE1967>3.0.CO;2-Q

Reference yield:

2-iodophenylamine (615-43-0) → 7-iodooxindole (31676-49-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 66 percent / NH₂OH*HCl; Na₂SO₄ / H₂O / 12 h / 45 °C

2.1: 98 percent / H₂SO₄ / 0.25 h / 70 °C

3.1: NH₂NH₂*H₂O / 1 h / 125 °C

3.2: 80 percent / aq. HCl / 2 h / 60 °C

With sulfuric acid; hydroxylamine hydrochloride; hydrazine hydrate; sodium sulfate; In water;

DOI:10.1021/ja049821k

Reference yield:

2-(hydroxyimino)-N-(2-iodophenyl)acetamide → 7-iodooxindole (31676-49-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 98 percent / H₂SO₄ / 0.25 h / 70 °C

2.1: NH₂NH₂*H₂O / 1 h / 125 °C

2.2: 80 percent / aq. HCl / 2 h / 60 °C

With sulfuric acid; hydrazine hydrate;

DOI:10.1021/ja049821k

upstream raw materials:

7-iodoisatin

2-iodophenylamine

2'-hydroxyimino-2-iodoacetanilide

Downstream raw materials:

2-(2-benzyloxycarbonylamino-3-{3-[3-(2-tert-butoxycarbonylamino-1-hydroxy-3-triisopropylsilanyloxy-propyl)-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-7-yl]-4-methoxy-phenyl}-propionylamino)-succinamic acid tert-butyl ester

2-(2-benzyloxycarbonylamino-3-{3-[3-(2-tert-butoxycarbonylamino-1-hydroxy-3-triisopropylsilanyloxy-propyl)-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-7-yl]-4-methoxy-phenyl}-propionylamino)-succinamic acid tert-butyl ester

2-(2-benzyloxycarbonylamino-3-{3-[3-(2-tert-butoxycarbonylamino-3-triisopropylsilanyloxy-propylidene)-2-oxo-2,3-dihydro-1H-indol-7-yl]-4-methoxy-phenyl}-propionylamino)-succinamic acid tert-butyl ester

(S)-2-((S)-3-{3-[(S)-3-((1R,2R)-2-Amino-1-hydroxy-3-triisopropylsilanyloxy-propyl)-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-7-yl]-4-methoxy-phenyl}-2-benzyloxycarbonylamino-propionylamino)-succinamic acid