Ethyl 2-amino-4-(2-fluorophenyl)-1,3-thiazole-5-carboxylate

Base Information

Chemical Name:Ethyl 2-amino-4-(2-fluorophenyl)-1,3-thiazole-5-carboxylate
CAS No.:247242-59-7
Molecular Formula:C₁₂H₁₁FN₂O₂S
Molecular Weight:266.296
Hs Code.:
DSSTox Substance ID:DTXSID00572499
Nikkaji Number:J1.164.192J
Wikidata:Q82460861
Mol file:247242-59-7.mol

Synonyms:ethyl 2-amino-4-(2-fluorophenyl)-1,3-thiazole-5-carboxylate;247242-59-7;DTXSID00572499

Suppliers and Price of Ethyl 2-amino-4-(2-fluorophenyl)-1,3-thiazole-5-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Ethyl 2-amino-4-(2-fluorophenyl)-1,3-thiazole-5-carboxylate

Chemical Property:

PSA：94.18000
LogP:2.63820
XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:266.05252693
Heavy Atom Count:18
Complexity:306

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(N=C(S1)N)C2=CC=CC=C2F

Technology Process of Ethyl 2-amino-4-(2-fluorophenyl)-1,3-thiazole-5-carboxylate

There total 2 articles about Ethyl 2-amino-4-(2-fluorophenyl)-1,3-thiazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: (E)-3-Amino-3-(2-fluoro-phenyl)-2-thiocyanato-acrylic acid ethyl ester

: 247242-59-7
2-amino-4-(2-fluoro-phenyl)-thiazole-5-carboxylic acid ethyl ester

Guidance literature:: With potassium carbonate; In tetrahydrofuran; for 240h; Heating;
DOI:10.1016/S0040-4039(99)01235-6

Reference yield:

: 247242-36-0,136757-04-5
ethyl 3-amino-3-(2-fluorophenyl)-2-propenoate

: 247242-59-7
2-amino-4-(2-fluoro-phenyl)-thiazole-5-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / dimethylsulfoxide / 2 h / 120 °C

2: 100 percent / K₂CO₃ / tetrahydrofuran / 240 h / Heating

With potassium carbonate; In tetrahydrofuran; dimethyl sulfoxide; 1: Substitution / 2: Cyclization;
DOI:10.1016/S0040-4039(99)01235-6