Chemical Property of 3-(azepan-1-ylsulfonyl)-N-(3-bromophenyl)benzamide
Chemical Property:
- PKA:12.28±0.70(Predicted)
- PSA：74.86000
- Density:1.469±0.06 g/cm3(Predicted)
- LogP:5.35780
- Storage Temp.:2-8°C
- Solubility.:DMSO: ≥15mg/mL
- XLogP3:3.8
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:4
- Exact Mass:436.04563
- Heavy Atom Count:26
- Complexity:570
- Purity/Quality:
-
97% *data from raw suppliers
AK 7 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:Xi
- Statements:
36
- Safety Statements:
26
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C1CCCN(CC1)S(=O)(=O)C2=CC=CC(=C2)C(=O)NC3=CC(=CC=C3)Br
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Description
The sirtuin SIRT2 is a deacetylase which targets α-tubulin, histone 4, forkhead transcription factors, and several other substrates. It has roles in metabolic diseases, cancer, age-related disorders, and neurodegenerative diseases, potentially including Alzheimer’s, Huntington’s, and Parkinson’s diseases. AK-7 is a cell- and brain-permeable inhibitor of SIRT2 (IC50 = 15.5 μM). In culture, it diminishes neuronal cell death induced by mutant huntingtin fragment. In addition, AK-7 down-regulates cholesterol biosynthetic gene expression and reduces total cholesterol levels in neurons in vivo.
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Uses
AK-7 is a deacetylase which targets α-tubulin, histone 4, forkhead transcription factors, and several other substrates it is also a selective SIRT2 inhibitor.
