2-(4-FLUORO-PHENYL)-N-HYDROXY-ACETAMIDINE

Base Information

• Chemical Name: 2-(4-FLUORO-PHENYL)-N-HYDROXY-ACETAMIDINE
• CAS No.: 42191-55-9
• Molecular Formula: C₈H₉FN₂O
• Molecular Weight: 168.171
• Mol file: 42191-55-9.mol

Synonyms:2-(4-FLUORO-PHENYL)-N-HYDROXY-ACETAMIDINE;BENZENEETHANIMIDAMIDE,4-FLUORO-N-HYDROXY-

Chemical Property of 2-(4-FLUORO-PHENYL)-N-HYDROXY-ACETAMIDINE

Chemical Property:

• Melting Point: 79.3 - 81.2 °C
• PSA: 58.61000
• LogP: 1.81490

Purity/Quality:

97% ^*data from raw suppliers

2-(4-Fluoro-phenyl)-N-hydroxy-acetamidine 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-FLUORO-PHENYL)-N-HYDROXY-ACETAMIDINE

There total 4 articles about 2-(4-FLUORO-PHENYL)-N-HYDROXY-ACETAMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-fluorophenylacetonitrile (459-22-3) → 2-(4-fluorophenyl)-N-hydroxyacetimidamide (925252-30-8,42191-55-9)

Guidance literature:

With hydroxylamine; In ethanol; water; at 90 ℃; for 18h;

Reference yield: 100.0%

→ 2-(4-fluorophenyl)-N-hydroxyacetimidamide (925252-30-8,42191-55-9)

Guidance literature:

Reference yield: 69.7%

4-fluorophenylacetonitrile (459-22-3) → 2-(4-fluorophenyl)-N-hydroxyacetimidamide (925252-30-8,42191-55-9)

Guidance literature:

With hydroxylamine hydrochloride; potassium carbonate; In ethanol; at 20 ℃; for 12.5h; Reflux;

DOI:10.1016/j.bmc.2014.07.036

upstream raw materials:

4-fluorophenylacetonitrile

Downstream raw materials:

(S)-2-Amino-2-[3-(4-fluoro-benzyl)-[1,2,4]oxadiazol-5-yl]-ethanol

3-(4-Fluorobenzyl)-5-(4-N-tBoc-aminophenyl)-1,2,4-oxadiazole

Refernces

• 1、 Chernyshov, Vladimir V.,Yarovaya, Olga I.,Esaulkova, Iana L.,Sinegubova, Ekaterina,Borisevich, Sophia S.,Popadyuk, Irina I.,Zarubaev, Vladimir V.,Salakhutdinov, Nariman F.. "Novel O-acylated amidoximes and substituted 1,2,4-oxadiazoles synthesised from (+)-ketopinic acid possessing potent virus-inhibiting activity against phylogenetically distinct influenza A viruses". . . Retrieved 2021/12/16.
• 2、 Choung, Wonken,Yang, Deokmo,Kim,Choi, Hyukjoon,Lee, Bo Ram,Park, Min,Jang, Su Min,Lim, Jae Soo,Kim, Woo Sik,Kim, Kyung-Hee,Chin, Jungwook,Jung, Kyungjin,Lee, Geumwoo,Hong,Jang, Tae-ho,Joo, Jeongmin,Hwang, Hayoung,Myung, Jayhyuk,Kim, Seong Heon. "Discovery of BR102375, a new class of non-TZD PPARγ full agonist for the treatment of type 2 diabetes". . p. 2275 - 2282. Retrieved 2019/06/27.