(5R)-5-phenyl-2-Pyrrolidinone

Base Information

• Chemical Name: (5R)-5-phenyl-2-Pyrrolidinone
• CAS No.: 313352-62-4
• Molecular Formula: C10H11NO
• Molecular Weight: 161.203
• Mol file: 313352-62-4.mol

Synonyms:(5R)-5-phenyl-2-Pyrrolidinone

Chemical Property of (5R)-5-phenyl-2-Pyrrolidinone

Chemical Property:

• Melting Point: 103 - 104 °C
• Boiling Point: 362.3±31.0 °C(Predicted)
• PSA: 29.10000
• Density: 1.108±0.06 g/cm3(Predicted)
• LogP: 1.96650

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5R)-5-phenyl-2-Pyrrolidinone

There total 42 articles about (5R)-5-phenyl-2-Pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-oxo-4-phenyl-butyric acid tert-butyl ester (55666-45-0) → (R)-(+)-5-phenylpyrrolidin-2-one (313352-62-4)

Guidance literature:

With Ru⁽²⁺⁾*2C₂H₃O₂^(1-)*C₇₇H₁₀₈O₆P₂; ammonium acetate; hydrogen; In 2,2,2-trifluoroethanol; at 90 ℃; for 24h; under 37503.8 Torr; Catalytic behavior;

Reference yield: 98.0%

ethyl 4(R)-amino-4-phenylbutyrate (313352-61-3) → (R)-(+)-5-phenylpyrrolidin-2-one (313352-62-4)

Guidance literature:

In methanol; dichloromethane;

Reference yield: 92.0%

3-(3-phenylpropyl)-5H-1,4,2-dioxazol-5-one → (R)-(+)-5-phenylpyrrolidin-2-one (313352-62-4)

Guidance literature:

With silver hexafluoroantimonate; C₃₀H₃₁ClN₃O₄RuS; In 1,2-dichloro-ethane; at 40 ℃; for 5h; Reagent/catalyst; enantioselective reaction; Catalytic behavior; Inert atmosphere; Glovebox;

DOI:10.1021/jacs.9b00535

upstream raw materials:

methyl (R)-5-[(3,5-dimethyl-4-methoxyphenyl)amino]-4-phenylbutanoate

methyl 4-[(3,5-dimethyl-4-methoxyphenyl)imino]-4-phenylbutanoate

ethyl 4(R)-amino-4-phenylbutyrate

ethyl 3-benzoylpropanoate

Downstream raw materials:

(R)-2-phenylpyrrolidine