2-Methoxy-5-phenylphenol

Base Information

• Chemical Name: 2-Methoxy-5-phenylphenol
• CAS No.: 37055-80-4
• Molecular Formula: C13H12O2
• Molecular Weight: 200.23318
• Hs Code.: 2909500000
• DSSTox Substance ID: DTXSID40559663
• Nikkaji Number: J283.856G
• Wikidata: Q82442447
• Mol file: 37055-80-4.mol

Synonyms:2-METHOXY-5-PHENYLPHENOL;37055-80-4;DTXSID40559663;4-Methoxy[1,1'-biphenyl]-3-ol;MFCD18314938;AKOS015907898;BS-28339;CS-0208922;D93450

Chemical Property of 2-Methoxy-5-phenylphenol

Chemical Property:

• PSA: 29.46000
• LogP: 3.06780
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 200.083729621
• Heavy Atom Count: 15
• Complexity: 187

Purity/Quality:

95% ^*data from raw suppliers

2-Methoxy-5-phenylphenol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)C2=CC=CC=C2)O

Technology Process of 2-Methoxy-5-phenylphenol

There total 22 articles about 2-Methoxy-5-phenylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-methoxylbiphenyl (613-37-6) → 4-methoxy-[1,1'-biphenyl]-3-ol (37055-80-4)

Guidance literature:

4-methoxylbiphenyl; With (TMP)2Cu(CN)Li₂; In tetrahydrofuran; at -78 - 0 ℃; for 2h; Inert atmosphere; Schlenk technique;

With tert.-butylhydroperoxide; In tetrahydrofuran; decane; at -78 ℃; for 0.5h; regioselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1021/jacs.6b03855

Reference yield: 71.0%

(1S,5S)-3-methoxy-1-methyl-6-phenyl-8-oxabicyclo[3.2.1]octa-3,6-dien-2-one → 4-methoxy-[1,1'-biphenyl]-3-ol (37055-80-4)

Guidance literature:

With boron trichloride; In dichloromethane; at 0 - 20 ℃; for 0.25h;

DOI:10.1039/c9cc09213g

Reference yield: 51.0%

1,1-dimethoxy-4-phenyl-3-cyclohexen-2-one (125101-69-1) → 4-methoxy-[1,1'-biphenyl]-3-ol (37055-80-4)

Guidance literature:

With acetic acid; for 1h; Heating;

upstream raw materials:

2-(4-methoxy-biphenyl-3-yloxy)-5-nitro-benzophenone

3,4-dimethoxy-1,1'-biphenyl

1,1-dimethoxy-4-phenyl-3-cyclohexen-2-one

3,4-dihydroxybiphenyl

Refernces

• 1、 Huber,Parker. "Application of NMR techniques to the structural elucidation of isomeric phenolic biphenyls". . p. 1274 - 1277. Retrieved 1990.
• 2、 Pilevar, Afsaneh,Hosseini, Abolfazl,?ekutor, Marina,Hausmann, Heike,Becker, Jonathan,Turke, Kevin,Schreiner, Peter R.. "Tuning the Reactivity of Peroxo Anhydrides for Aromatic C-H Bond Oxidation". . p. 10070 - 10079. Retrieved 2018/09/06.