(1R)-N-{1-[3-(trifluoromethyl)phenyl]ethyl}methylamine

Base Information

• Chemical Name: (1R)-N-{1-[3-(trifluoromethyl)phenyl]ethyl}methylamine
• CAS No.: 1212101-09-1
• Molecular Formula: C10H12F3N
• Molecular Weight: 203.2041896
• Hs Code.: 2921490090
• Mol file: 1212101-09-1.mol

Synonyms:(1R)-N-{1-[3-(trifluoromethyl)phenyl]ethyl}methylamine;(1R)-N-Methyl-1-[3-(trifluoromethyl)phenyl]ethylamine

Chemical Property of (1R)-N-{1-[3-(trifluoromethyl)phenyl]ethyl}methylamine

Chemical Property:

• PSA: 12.03000
• LogP: 3.37670

Purity/Quality:

97% ^*data from raw suppliers

((1R)-1-[3-(TRIFLUOROMETHYL)PHENYL]ETHYL)METHYLAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R)-N-{1-[3-(trifluoromethyl)phenyl]ethyl}methylamine

There total 4 articles about (1R)-N-{1-[3-(trifluoromethyl)phenyl]ethyl}methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-methyl-[1-(3'-trifluoromethylphenyl)ethylidene]amine (118797-81-2) → methyl[(1R)-1-[3-(trifluoromethyl)phenyl]ethyl]amine (1212101-09-1,1212264-66-8)

Guidance literature:

With C₃₄H₃₇FeN₃O₂Si; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; In hexane; toluene; at -40 - 20 ℃; for 14h; enantioselective reaction;

DOI:10.1002/anie.202006557

Reference yield:

3'-(trifluoromethyl)acetophenone (349-76-8) → methyl[(1R)-1-[3-(trifluoromethyl)phenyl]ethyl]amine (1212101-09-1,1212264-66-8)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 96 h / 20 °C / Schlenk technique; Sealed tube; Inert atmosphere; Molecular sieve

2: C₃₄H₃₇FeN₃O₂Si; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane / toluene; hexane / 14 h / -40 - 20 °C

With C₃₄H₃₇FeN₃O₂Si; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; In ethanol; hexane; toluene;

DOI:10.1002/anie.202006557

Reference yield:

(R)-α-(m-(trifluoromethyl)phenyl)ethylamine (127852-30-6) → methyl[(1R)-1-[3-(trifluoromethyl)phenyl]ethyl]amine (1212101-09-1,1212264-66-8)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 10 h / 70 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 70 °C / Inert atmosphere

With lithium aluminium tetrahydride; In tetrahydrofuran;

upstream raw materials:

(R)-α-(m-(trifluoromethyl)phenyl)ethylamine

tert-butyl N-[(1R)-1-[3-(trifluoromethyl)phenyl]ethyl]carbamate

N-methyl-[1-(3'-trifluoromethylphenyl)ethylidene]amine

3'-(trifluoromethyl)acetophenone