4-AMinoMethyl-1-Boc-3,3-d...

Base Information

• Chemical Name: 4-AMinoMethyl-1-Boc-3,3-d...
• CAS No.: 1303973-22-9
• Molecular Formula: C₁₁H₂₀F₂N₂O₂
• Molecular Weight: 250.289
• Hs Code.: 2933399090
• Mol file: 1303973-22-9.mol

Synonyms:4-AMinoMethyl-1-Boc-3,3-d...;tert-butyl 4-(aMinoMethyl)-3,3-difluoropiperidine-1-carboxylate;4-AMinoMethyl-1-Boc-3,3-difluoropiperidine

Chemical Property of 4-AMinoMethyl-1-Boc-3,3-d...

Chemical Property:

• Boiling Point: 303.4±42.0 °C(Predicted)
• PKA: 10.13±0.29(Predicted)
• PSA: 55.56000
• Density: 1.15±0.1 g/cm3(Predicted)
• LogP: 2.47560
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%,99%, ^*data from raw suppliers

Tert-Butyl4-(Aminomethyl)-3,3-Difluoropiperidine-1-Carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-AMinoMethyl-1-Boc-3,3-d...

There total 13 articles about 4-AMinoMethyl-1-Boc-3,3-d... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-(tert-butoxy)carbonyl-3,3-difluoro-4-(benzyloxycarbonylaminomethyl)piperidine (1373503-45-7) → tert-butyl 4-(aminomethyl)-3,3-difluoropiperidine-1-carboxylate (1303973-22-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 16 - 25 ℃; for 6h; under 760.051 Torr;

Reference yield: 93.0%

(R)-tert-butyl 4-((((benzyloxy)carbonyl)amino)methyl)-3,3-difluoropiperidine-1-carboxylate (1373503-45-7) → (-)-R-tert-butyl 4-(aminomethyl)-3,3-difluoropiperidine-1-carboxylate (1303973-22-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 13h; under 760.051 Torr;

Reference yield: 91.0%

(S)-tert-butyl 4-((((benzyloxy)carbonyl)amino)methyl)-3,3-difluoropiperidine-1-carboxylate (1373503-45-7) → (S)-tert-butyl 4-(aminomethyl)-3,3-difluoropiperidine-1-carboxylate (1303973-22-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol;

upstream raw materials:

N-(tert-butoxy)carbonyl-3,3-difluoro-4-(benzyloxycarbonylaminomethyl)piperidine

tert-butyl 4-(2-ethoxy-2-oxoethyl)-3,3-difluoropiperidine-1-carboxylate

(±)-2-(1-( tert-butoxycarbonyl)-3,3-difluoropiperidin-4-yl)acetic acid

tert-butyl 3,3-difluoro-4,4-dihydroxypiperidine-1-carboxylate

Refernces

• 1、 -. "1-R 1 -3, 3-difluoro-4-R 2-piperidine and its derivatives preparation method". Paragraph 0042; 0043; 0044; 0045; 0046. . Retrieved 2016/10/08.