Proadifen hydrochloride

Base Information

• Chemical Name: Proadifen hydrochloride
• CAS No.: 62-68-0
• Molecular Formula: C23H31 N O2 . Cl H
• Molecular Weight: 389.966
• Hs Code.: 29221990
• European Community (EC) Number: 688-917-8
• NSC Number: 758181,170997,39690
• UNII: 30624AA6X2
• DSSTox Substance ID: DTXSID1045792
• Wikidata: Q26840729
• NCI Thesaurus Code: C66468
• ChEMBL ID: CHEMBL347036
• Mol file: 62-68-0.mol

Synonyms:Acetate, Diethylaminoethyldiphenylpropyl;Diethylaminoethyldiphenylpropyl Acetate;Hydrochloride, Proadifen;Proadifen;Proadifen Hydrochloride;Propyladiphenin;SK 525A;SK and F 525 A;SK and F-525-A;SK and F525A;SK-525A;SK525A;SKF 525 A;SKF-525-A;SKF-525A;SKF525A

Chemical Property of Proadifen hydrochloride

Chemical Property:

• Vapor Pressure: 1.13E-08mmHg at 25°C
• Melting Point: 122-123°C
• Boiling Point: 460.8°C at 760 mmHg
• Flash Point: 132.3°C
• PSA: 29.54000
• LogP: 5.45980
• Storage Temp.: −20°C
• Solubility.: Soluble in DMSO (up to 20 mg/ml)
• Water Solubility.: Soluble in methanol or water
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 11
• Exact Mass: 389.2121570
• Heavy Atom Count: 27
• Complexity: 375

Purity/Quality:

99.5% ^*data from raw suppliers

SKF-525A, Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 36-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCCC(C1=CC=CC=C1)(C2=CC=CC=C2)C(=O)OCCN(CC)CC.Cl
• Description: SKF 525A is a widely used, nonspecific cytochrome P (CYP)450 inhibitor that demonstrates 100% inhibition of the various CYP450 isoforms at 1-100 μM. It therefore potentiates the effects of many different drugs by inhibiting their metabolism (IC50 values in the μM range when tested using human liver microsomes). SKF 525A inhibits CYP450-dependent arachidonic acid conversion to active EET metabolites, antagonizing the recovery of functional calcium pools. It also acts as a noncompetitive inhibitor of acetylcholine nicotinic receptors (IC50 = 19 μM in mouse skeletal muscle).
• Uses: An inhibitor of NOS1, AChR, cytochrome P-450, and KIR6.1. Cytochrome P-459 inhibitor; blocks glibenclamide-sensitive K+ channels; inhibits neuronal nitric oxide synthetase; stimulates endothelial cell prostacyclin while inhibiting platelet thromboxane synthesis Proadifen hydrochloride is an inhibitor of NOS1, AChR, cytochrome P-450, and KIR6. Proadifen hydrochloride bind to the protein moiety of P-450, also reduced the hypoxic response. of Proadifen hydrochloride have good antiarrhythmic effects. SKF-525A substantially reduced the depletion of cardiac norepinephrine.