PAz-PC

Base Information

• Chemical Name: PAz-PC
• CAS No.: 117746-89-1
• Molecular Formula: C33H64NO10P
• Molecular Weight: 665.835721
• Mol file: 117746-89-1.mol

Synonyms:PazePC;16:0-09:0 (ALDO) PC

Chemical Property of PAz-PC

Chemical Property:

• PSA: 158.30000
• LogP: 8.01600
• Storage Temp.: -20°C
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

PazePC ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: PazePC is an oxidatively modified phospholipid that modulates reactions between Bax (a pro-apoptotic protein) and mitochondrial membranes under intracellular oxidative stress, often resulting in cell death. PazePC is found in low density cholesterol (LDL).

Technology Process of PAz-PC

There total 4 articles about PAz-PC which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

azeleic acid anhydride (4196-95-6) + 1-palmitoyl-2-lyso-sn-glycero-3-phosphatidylcholine (17364-17-9) → 1-palmitoyl-2-azeleyl-sn-glycero-3-phosphatidylcholine (117205-52-4,117746-89-1)

Guidance literature:

With dmap; In chloroform; for 48h;

DOI:10.1021/jo0105383

Reference yield:

azelaic acid (123-99-9,26776-28-3) + 1-palmitoyl-sn-glycero-3-phosphocholine (17364-16-8,17364-17-9,17364-18-0,14863-27-5) → 1-hexadecanoyl-2-(9-carboxynonanoyl)glycerophosphocholine (117205-52-4,117746-89-1)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In chloroform;

Reference yield:

lecithin (6931-84-6,70094-88-1,128114-92-1,17708-90-6,159701-21-0) → 1-palmitoyl-sn-glycero-3-phosphocholine + 1-palmitoyl-2-(9'-oxo-nonanoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9-carboxynonanoyl)glycerophosphocholine (117205-52-4,117746-89-1)

Guidance literature:

With oxygen; at 22.84 ℃; for 24h;

DOI:10.1016/j.chemphyslip.2014.09.003

upstream raw materials:

azelaic acid

1-palmitoyl-sn-glycero-3-phosphocholine

lecithin

azeleic acid anhydride

Downstream raw materials:

C₅₁H₉₀N₃O₁₄P

Refernces

• 1、 -. "LIPIDS CAPABLE OF CONFORMATIONAL CHANGE AND THEIR USE IN FORMULATIONS TO DELIVER THERAPEUTIC AGENTS TO CELLS". Page/Page column 150; 151. . Retrieved 2013/03/28.