(R)-1-(4-Chlorophenyl)-2,2,2-trifluoroethanaMine dihydrochloride

Base Information

• Chemical Name: (R)-1-(4-Chlorophenyl)-2,2,2-trifluoroethanaMine dihydrochloride
• CAS No.: 1187931-01-6
• Molecular Formula: C8H9Cl3F3N
• Molecular Weight: 282.5179696
• Mol file: 1187931-01-6.mol

Synonyms:(R)-1-(4-Chlorophenyl)-2,2,2-trifluoroethanaMine dihydrochloride;(R)-2,2,2-Trifluoro-1-(4-chloro-phenyl)-ethylamine;(1R)-1-(4-Chlorophenyl)-2,2,2-trifluoroethan-1-amine

Chemical Property of (R)-1-(4-Chlorophenyl)-2,2,2-trifluoroethanaMine dihydrochloride

Chemical Property:

• Boiling Point: 238.3±40.0 °C(Predicted)
• PKA: 5.94±0.10(Predicted)
• PSA: 26.02000
• Density: 1.352±0.06 g/cm3(Predicted)
• LogP: 3.60240
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

(R)-2,2,2-Trifluoro-1-(4-chloro-phenyl)-ethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-1-(4-Chlorophenyl)-2,2,2-trifluoroethanaMine dihydrochloride

There total 1 articles about (R)-1-(4-Chlorophenyl)-2,2,2-trifluoroethanaMine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

(R)-N-[1-(4-chlorophenyl)-2,2,2-trifluoroethyl]-4-meth-oxyaniline (1453102-14-1) → (R)-1-(4-chlorophenyl)-2,2,2-trifluoroethanamine (1187931-01-6,766498-73-1)

Guidance literature:

With sulfuric acid; periodic acid; In water; acetonitrile; at 20 ℃; for 24h;

DOI:10.1002/adsc.201301115

Reference yield: 82.0%

2,6-dichloropyridine-4-carbaldehyde (113293-70-2) + (R)-1-(4-chlorophenyl)-2,2,2-trifluoroethanamine (1187931-01-6,766498-73-1) → (R)-1-(4-chlorophenyl)-N-[(2,6-dichloropyridin-4-yl)methyl]-2,2,2-trifluoroethanamine

Guidance literature:

2,6-dichloropyridine-4-carbaldehyde; (R)-1-(4-chlorophenyl)-2,2,2-trifluoroethanamine; In methanol; Reflux;

With sodium tetrahydroborate; In methanol; at 20 ℃;

DOI:10.1002/adsc.201301115

upstream raw materials:

(R)-N-[1-(4-chlorophenyl)-2,2,2-trifluoroethyl]-4-meth-oxyaniline

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