Methyl 1-(4-hydroxyphenyl)cyclopropane-1-carboxylate

Base Information

• Chemical Name: Methyl 1-(4-hydroxyphenyl)cyclopropane-1-carboxylate
• CAS No.: 779199-69-8
• Molecular Formula: C11H12O3
• Molecular Weight: 192.214
• Mol file: 779199-69-8.mol

Synonyms:Methyl 1-(4-hydroxyphenyl)cyclopropane-1-carboxylate;Methyl 1-(4-hydroxyphenyl)cyclopropanecarboxylate;1-(4-hydroxy-phenyl)-cyclopropanecarboxylic acid methyl ester

Chemical Property of Methyl 1-(4-hydroxyphenyl)cyclopropane-1-carboxylate

Chemical Property:

• Boiling Point: 303.6±35.0 °C(Predicted)
• PKA: 10.18±0.15(Predicted)
• PSA: 46.53000
• Density: 1.265±0.06 g/cm3(Predicted)
• LogP: 1.59680

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl1-(4-Hydroxyphenyl)cyclopropane-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 1-(4-hydroxyphenyl)cyclopropane-1-carboxylate

There total 8 articles about Methyl 1-(4-hydroxyphenyl)cyclopropane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C18H18O3 → 1-(4-hydroxyphenyl)cyclopropanecarboxylic acid methyl ester (779199-69-8)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethanol; at 20 ℃; for 17h; under 760.051 Torr;

Reference yield: 95.0%

1-(4-methoxyphenyl)cyclopropanecarboxylic acid methyl ester (779206-51-8) → 1-(4-hydroxyphenyl)cyclopropanecarboxylic acid methyl ester (779199-69-8)

Guidance literature:

1-(4-methoxyphenyl)cyclopropanecarboxylic acid methyl ester; With aluminum (III) chloride; In dichloromethane; ethanethiol; at 0 ℃; for 0.833333h;

With water; In dichloromethane; ethanethiol;

Reference yield: 71.0%

C23H15F4O2S2(1+)*BF4(1-) → 1-(4-hydroxyphenyl)cyclopropanecarboxylic acid methyl ester (779199-69-8)

Guidance literature:

With copper(I) thiophene-2-carboxylate; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; water; In acetonitrile; at 30 ℃; for 16h; Irradiation; Inert atmosphere;

DOI:10.1002/anie.201908718

upstream raw materials:

1-(4-methoxyphenyl)cyclopropanecarboxylic acid methyl ester

1-(4-methoxyphenyl)-1-cyclopropanecarboxylic acid

Methyl 4-hydroxyphenylacetate

(4-benzyloxy-phenyl)-acetic acid methyl ester

Downstream raw materials:

1-[4-(2-tert-butoxycarbonyl-ethoxy)phenyl]cyclopropanecarboxylic acid methyl ester

1-(4-hydroxy-3,5-diiodophenyl)cyclopropanecarboxylic acid methyl ester

1-(benzofuran-5-yl)cyclopropanecarboxylic acid

1-[3,5-diiodo-4-(2-methyl-allyloxy)phenyl]cyclopropanecarboxylic acid methyl ester

Refernces

• 1、 -. "BIARYL DERIVATIVE AND MEDICINE CONTAINING SAME". . . Retrieved 2018/08/07.
• 2、 -. "Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases". Paragraph 1550. . Retrieved 2015/09/22.