Iso Ribavirin (Ribavirin Impurity G)

Base Information

• Chemical Name: Iso Ribavirin (Ribavirin Impurity G)
• CAS No.: 39030-43-8
• Molecular Formula: C8H12N4O5
• Molecular Weight: 244.207
• Mol file: 39030-43-8.mol

Synonyms:Iso Ribavirin (Ribavirin Impurity G);IsoRibovarin (impurity G);1-β-D-Ribofuranosyl-

Chemical Property of Iso Ribavirin (Ribavirin Impurity G)

Chemical Property:

• Melting Point: 58-60°C
• Boiling Point: 639.8±65.0 °C(Predicted)
• PKA: 12.95±0.70(Predicted)
• PSA: 143.72000
• Density: 2.08±0.1 g/cm3(Predicted)
• LogP: -2.31120
• Storage Temp.: -20?C Freezer
• Solubility.: DMSO (Slightly), Methanol (Slightly, Sonicated)

Purity/Quality:

99% ^*data from raw suppliers

Iso Ribavirin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ribavirin impurity G. The N-isomer of Ribavirin.

Technology Process of Iso Ribavirin (Ribavirin Impurity G)

There total 6 articles about Iso Ribavirin (Ribavirin Impurity G) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1-(2,3-O-Isopropyliden-β-D-ribofuranosyl)-1H-1,2,4-triazol-5-carboxamid (79437-82-4) → 1-β-D-ribofuranosyl-1H-1,2,4-triazole-5-carboxamide (39030-43-8)

Guidance literature:

With ion exchanger Merck I (H+); In water; acetone; Ambient temperature;

DOI:10.1002/cber.19811140814

Reference yield: 17.0%

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose (6974-32-9) + methyl 1H-1,2,4-triazole-3-carboxylate (4928-88-5) → 1-β-D-ribofuranosyl-1H-1,2,4-triazole-5-carboxamide (39030-43-8) + ribavirin (36791-04-5,66510-90-5)

Guidance literature:

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose; methyl 1H-1,2,4-triazole-3-carboxylate; With N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 130 ℃; for 0.0833333h; microwave irradiation;

With ammonia; In methanol; at 50 ℃; for 16h;

DOI:10.1021/jo061885l

Reference yield:

methyl 1-(2',3',3''-tri-O-benzoyl-apio-β-D-furanosyl)triazole-5-carboxylate (39925-13-8) → 1-β-D-ribofuranosyl-1H-1,2,4-triazole-5-carboxamide (39030-43-8)

Guidance literature:

With ammonia; In methanol; at 24 ℃;

upstream raw materials:

1-(2,3-O-Isopropyliden-β-D-ribofuranosyl)-1H-1,2,4-triazol-5-carboxamid

methyl 1-(2',3',3''-tri-O-benzoyl-apio-β-D-furanosyl)triazole-5-carboxylate

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

methyl 1H-1,2,4-triazole-3-carboxylate