N-[4-[(Trifluoroacetyl)amino]benzoyl-d4]-L-glutamic Acid Dimethyl Ester

Base Information

Chemical Name:N-[4-[(Trifluoroacetyl)amino]benzoyl-d4]-L-glutamic Acid Dimethyl Ester
CAS No.:461426-33-5
Molecular Formula:C16H13D4F3N2O6
Molecular Weight:394.335836712
Hs Code.:
Mol file:461426-33-5.mol

Synonyms:N-[4-[(Trifluoroacetyl)amino]benzoyl-d4]-L-glutamic Acid Dimethyl Ester

Suppliers and Price of N-[4-[(Trifluoroacetyl)amino]benzoyl-d4]-L-glutamic Acid Dimethyl Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-[4-[(Trifluoroacetyl)amino]benzoyl-d4]-L-glutamicAcidDimethylEster
1mg
$ 130.00

Total 1 raw suppliers

Chemical Property of N-[4-[(Trifluoroacetyl)amino]benzoyl-d4]-L-glutamic Acid Dimethyl Ester

Chemical Property:

PSA：110.80000
LogP:1.87590
Solubility.:Methanol

Purity/Quality:

97% ^*data from raw suppliers

N-[4-[(Trifluoroacetyl)amino]benzoyl-d4]-L-glutamicAcidDimethylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Intermediate in the production of labelled 5-Methyltetrahydrofolic Acid metabolites

Technology Process of N-[4-[(Trifluoroacetyl)amino]benzoyl-d4]-L-glutamic Acid Dimethyl Ester

There total 3 articles about N-[4-[(Trifluoroacetyl)amino]benzoyl-d4]-L-glutamic Acid Dimethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6525-53-7,16422-27-8,40149-68-6
L-glutamic acid dimethyl ester

: 461426-32-4
trifluoroacetyl-[2H₄]4-aminobenzoic acid

: 461426-33-5
trifluoroacetyl-[2H₄]4-aminobenzoylglutamate dimethylester

Guidance literature:: trifluoroacetyl-[2H₄]4-aminobenzoic acid; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 20 ℃; for 0.5h;

L-glutamic acid dimethyl ester; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 4h;
DOI:10.1021/jf025571k

Reference yield:

: 150-13-0,159246-81-8,8014-65-1
4-amino-benzoic acid

: 461426-33-5
trifluoroacetyl-[2H₄]4-aminobenzoylglutamate dimethylester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 58.1 percent / deuterium oxide; Pd/C / 2 h / 200 °C

2.1: 2 h / 20 °C

3.1: dicyclohexylcarbodiimide; 1-hydroxybenzotriazole / tetrahydrofuran / 0.5 h / 20 °C

3.2: diisopropylethylamine / tetrahydrofuran / 4 h / 20 °C

With palladium on activated charcoal; water-d2; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran;
DOI:10.1021/jf025571k

Reference yield:

: 350820-01-8
4-aminobenzoic-2,3,5,6-d₄ acid

: 461426-33-5
trifluoroacetyl-[2H₄]4-aminobenzoylglutamate dimethylester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2 h / 20 °C

2.1: dicyclohexylcarbodiimide; 1-hydroxybenzotriazole / tetrahydrofuran / 0.5 h / 20 °C

2.2: diisopropylethylamine / tetrahydrofuran / 4 h / 20 °C

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran;
DOI:10.1021/jf025571k