tert-butyl 4-(3-methoxy-4-(4-(2-oxo-2H-benzo[d][1,3]oxazin-1(4H)-yl)piperidine-1-carbonyl)phenoxy)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(3-methoxy-4-(4-(2-oxo-2H-benzo[d][1,3]oxazin-1(4H)-yl)piperidine-1-carbonyl)phenoxy)piperidine-1-carboxylate
CAS No.:162042-41-3
Molecular Formula:C₃₁H₃₉N₃O₇
Molecular Weight:565.667
Hs Code.:
Mol file:162042-41-3.mol

Synonyms:tert-butyl 4-(3-methoxy-4-(4-(2-oxo-2H-benzo[d][1,3]oxazin-1(4H)-yl)piperidine-1-carbonyl)phenoxy)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(3-methoxy-4-(4-(2-oxo-2H-benzo[d][1,3]oxazin-1(4H)-yl)piperidine-1-carbonyl)phenoxy)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(3-methoxy-4-(4-(2-oxo-2H-benzo[d][1,3]oxazin-1(4H)-yl)piperidine-1-carbonyl)phenoxy)piperidine-1-carboxylate

There total 10 articles about tert-butyl 4-(3-methoxy-4-(4-(2-oxo-2H-benzo[d][1,3]oxazin-1(4H)-yl)piperidine-1-carbonyl)phenoxy)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 162045-38-7
4-(N-t-Butoxycarbonyl-4-piperidinyloxy)-2-methoxy-benzoic acid

: 162045-31-0
1-piperidin-4-yl-1,4-dihydro-2H-3,1-benzoxazin-2-one hydrochloride

: 162042-41-3
4-{3-Methoxy-4-[4-(2-oxo-4H-benzo[d][1,3]oxazin-1-yl)-piperidine-1-carbonyl]-phenoxy}-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm00023a002

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 162042-41-3
4-{3-Methoxy-4-[4-(2-oxo-4H-benzo[d][1,3]oxazin-1-yl)-piperidine-1-carbonyl]-phenoxy}-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: AcOH / toluene / 6 h / Heating

2: NaCNBH₃, AcOH / toluene; tetrahydrofuran / 24 h / Ambient temperature

3: 75 percent / DIEA / tetrahydrofuran / 73 h / 0 - 20 °C

4: 95 percent / HCl gas / ethyl acetate / 2 h / 0 - 20 °C

5: 90 percent / HOBT, EDC, DIEA / dimethylformamide / 24 h / Ambient temperature

With hydrogenchloride; sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm9800797

Reference yield:

: 162045-30-9
1-(N-t-butyloxy-carbonyl-4-piperidinyl)-4H-3,1-benzoxazin-2(1H)-one

: 162042-41-3
4-{3-Methoxy-4-[4-(2-oxo-4H-benzo[d][1,3]oxazin-1-yl)-piperidine-1-carbonyl]-phenoxy}-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / HCl gas / ethyl acetate / 2 h / 0 - 20 °C

2: 90 percent / HOBT, EDC, DIEA / dimethylformamide / 24 h / Ambient temperature

With hydrogenchloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm9800797