IKF 309

Base Information

• Chemical Name: IKF 309
• CAS No.: 688046-61-9
• Molecular Formula: C₁₈H₂₀ClNO₅
• Molecular Weight: 365.814
• Mol file: 688046-61-9.mol

Synonyms:(5-Chloro-2-Methoxy-4-Methyl-3-pyridinyl)(2,3,4-triMethoxy-6-Methylphenyl)Methanone;3-(2,3,4-TriMethoxy-6-Methylbenzoyl)-5-chloro-2-Methoxy-4-Methylpyridine;IKF 309;Pyriofenone

Chemical Property of IKF 309

Chemical Property:

• Vapor Pressure: 6.59E-11mmHg at 25°C
• Boiling Point: 519.8°C at 760 mmHg
• PKA: -0.80±0.28(Predicted)
• Flash Point: 268.2°C
• PSA: 66.88000
• Density: 1.214g/cm³
• LogP: 3.61720
• Storage Temp.: Amber Vial, -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

Pyriofenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: IKF 309 is a fungicidal imidazole derivative use for controlling plant diseases caused by fungal plant pathogens. Pyriofenone is a fungicide.

Technology Process of IKF 309

There total 11 articles about IKF 309 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(2,3,4-trimethoxy-6-methylphenyl)(5-chloro-2-methoxy-4-methyl-pyridin-3-yl)methanol (688047-04-3) → 3-(2,3,4-trimethoxy-6-methylbenzoyl)-5-chloro-2-methoxy-4-methylpyridine (688046-61-9)

Guidance literature:

With manganese(IV) oxide; In toluene; for 1h; Product distribution / selectivity; Heating / reflux;

Reference yield: 75.0%

3-(2,3,4-trimethoxy-6-methylbenzoyl)-4,5-dichloro-2-methoxypyridine (688046-43-7) + Trimethylboroxine (823-96-1) → 3-(2,3,4-trimethoxy-6-methylbenzoyl)-5-chloro-2-methoxy-4-methylpyridine (688046-61-9)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; for 10h; Heating / reflux;

Reference yield: 57.0%

2,3,4-trimethoxy-6-methylbenzoyl chloride (851607-36-8) + 5-chloro-2-methoxy-4-methyl-3-pyridylcopper (1227366-30-4) → 3-(2,3,4-trimethoxy-6-methylbenzoyl)-5-chloro-2-methoxy-4-methylpyridine (688046-61-9)

Guidance literature:

2,3,4-trimethoxy-6-methylbenzoyl chloride; 5-chloro-2-methoxy-4-methyl-3-pyridylcopper; In tetrahydrofuran; at -78 - 20 ℃; for 3h;

With ammonia; water; In tetrahydrofuran; at 20 ℃; Product distribution / selectivity;

upstream raw materials:

3-(2,3,4-trimethoxy-6-methylbenzoyl)-4,5-dichloro-2-methoxypyridine

Trimethylboroxine

3-bromo-5-chloro-2-methoxy-4-methylpyridine

(2,3,4-trimethoxy-6-methylphenyl)boronic acid