(S)-Methyl 2-((tert-butoxycarbonyl)aMino)-2-((1r,4S)-4-hydroxycyclohexyl)acetate

Base Information

• Chemical Name: (S)-Methyl 2-((tert-butoxycarbonyl)aMino)-2-((1r,4S)-4-hydroxycyclohexyl)acetate
• CAS No.: 463349-85-1
• Molecular Formula: C14H25NO5
• Molecular Weight: 287.356
• Mol file: 463349-85-1.mol

Synonyms:(S)-Methyl 2-((tert-butoxycarbonyl)aMino)-2-((1r,4S)-4-hydroxycyclohexyl)acetate

Chemical Property of (S)-Methyl 2-((tert-butoxycarbonyl)aMino)-2-((1r,4S)-4-hydroxycyclohexyl)acetate

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-Methyl 2-((tert-butoxycarbonyl)aMino)-2-((1r,4S)-4-hydroxycyclohexyl)acetate

There total 10 articles about (S)-Methyl 2-((tert-butoxycarbonyl)aMino)-2-((1r,4S)-4-hydroxycyclohexyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-Nα-(tert-butyloxycarbonyl)-4-hydroxyphenylglycine methyl ester (225517-15-7) → methyl (2S)-[(tert-butoxycarbonyl)amino](4-hydroxycyclohexyl)ethanoate trans-isomer (463349-85-1) + methyl (2S)-[(tert-butoxycarbonyl)amino](4-hydroxycyclohexyl)ethanoate cis-isomer (667898-96-6)

Guidance literature:

With hydrogen; acetic acid; platinum(IV) oxide; for 16h; under 2327.17 Torr;

DOI:10.1016/j.bmcl.2003.10.016

Reference yield:

(S)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-oxocyclohexyl)acetate (848498-04-4) → methyl (2S)-[(tert-butoxycarbonyl)amino](4-hydroxycyclohexyl)ethanoate trans-isomer (463349-85-1) + methyl (2S)-[(tert-butoxycarbonyl)amino](4-hydroxycyclohexyl)ethanoate cis-isomer (667898-96-6)

Guidance literature:

(S)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-oxocyclohexyl)acetate; With sodium tetrahydroborate; In methanol; at 0 ℃; for 0.333333h;

With citric acid; In methanol; water; pH=~ 1;

Reference yield:

(S)-hydroxyphenylglycine (32462-30-9) → methyl (2S)-[(tert-butoxycarbonyl)amino](4-hydroxycyclohexyl)ethanoate trans-isomer (463349-85-1)

Guidance literature:

Multi-step reaction with 3 steps

1: HCl / 45 °C

2: DIEA / ethyl acetate

3: H₂; AcOH / PtO₂ / 16 h / 2327.17 Torr

With hydrogenchloride; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; In ethyl acetate;

DOI:10.1016/j.bmcl.2003.10.016

upstream raw materials:

(S)-N^α-(tert-butyloxycarbonyl)-4-hydroxyphenylglycine methyl ester

(S)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-oxocyclohexyl)acetate

(S)-hydroxyphenylglycine

(S)-methyl 2-amino-2-(4-hydroxyphenyl)acetate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 463349-85-1 (S)-Methyl 2-((tert-butoxycarbonyl)aMino)-2-((1r,4S)-4-hydroxycyclohexyl)acetate

Send

Send

Metric Ton KG G Pound L ML

Send

Send