Boc-(S)-2-amino-2-(4-hydroxyphenyl)acetic acid

Base Information

• Chemical Name: Boc-(S)-2-amino-2-(4-hydroxyphenyl)acetic acid
• CAS No.: 69651-48-5
• Molecular Formula: C13H17NO5
• Molecular Weight: 267.282
• Hs Code.: 2924299090
• Mol file: 69651-48-5.mol

Synonyms:Boc-(S)-2-amino-2-(4-hydroxyphenyl)acetic acid

Chemical Property of Boc-(S)-2-amino-2-(4-hydroxyphenyl)acetic acid

Chemical Property:

• PSA: 99.35000
• LogP: 2.24700
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(S)-2-((tert-Butoxycarbonyl)amino)-2-(4-hydroxyphenyl)aceticacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Boc-(S)-2-amino-2-(4-hydroxyphenyl)acetic acid

There total 5 articles about Boc-(S)-2-amino-2-(4-hydroxyphenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + (S)-hydroxyphenylglycine (32462-30-9) → N-tert-butyloxycarbonyl-L-4-hydroxyphenylglycine (69651-48-5)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; water; at 20 ℃;

DOI:10.1055/s-2008-1078209

Reference yield: 98.0%

di-tert-butyl dicarbonate (24424-99-5) + D-4-hydroxyphenylglycine (22818-40-2) → N-tert-butyloxycarbonyl-L-4-hydroxyphenylglycine (69651-48-5)

Guidance literature:

With triethylamine; In tetrahydrofuran; water; for 16h; Ambient temperature; pH=8;

DOI:10.1016/S0040-4020(01)92149-0

Reference yield: 89.0%

t-butoxycarbonyl bromide + (S)-hydroxyphenylglycine (32462-30-9) → N-tert-butyloxycarbonyl-L-4-hydroxyphenylglycine (69651-48-5)

Guidance literature:

(S)-hydroxyphenylglycine; With sodium bromide; In acetonitrile; for 2h; Reflux;

t-butoxycarbonyl bromide; In acetonitrile; at 65 ℃; for 20h; Concentration; Temperature; Reflux;

upstream raw materials:

di-tert-butyl dicarbonate

D-4-hydroxyphenylglycine

(S)-hydroxyphenylglycine

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

Downstream raw materials:

(R)-1-(4-(benzyloxy)phenyl)-2-methoxy-2-oxoethan-1-aminium chloride

N-tert-butoxycarbonyl-O-tert-butyldimethylsilyl-(S)-4-hydroxyphenylglycine

BOC-L-Hpg-D-α-Thr-OBn

BOC-L-Hpg-D-Hpg-OBn

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