(R)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE-HCl

Base Information

• Chemical Name: (R)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE-HCl
• CAS No.: 856645-99-3
• Molecular Formula: C₉H₁₀F₃N*ClH
• Molecular Weight: 225.641
• Hs Code.: 2921499090
• Mol file: 856645-99-3.mol

Synonyms:(R)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE-HCl;(R)-1-(4-(trifluoroMethyl)phenyl)ethanaMine hydrochloride;BenzeneMethanaMine, α-Methyl-4-(trifluoroMethyl)-, hydrochloride (1:1), (αR);(R)-1-(4-(Trifluoromethyl)phenyl)ethanamine HCl

Chemical Property of (R)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE-HCl

Chemical Property:

• PSA: 26.02000
• LogP: 4.22740
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

(R)-1-(4-(Trifluoromethyl)phenyl)ethanamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE-HCl

There total 11 articles about (R)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE-HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-(4-trifluoromethylphenyl)ethanone (709-63-7) → C9H10F3N*(x)ClH (856645-99-3)

Guidance literature:

1-(4-trifluoromethylphenyl)ethanone; With ammonium hydroxide; hydrogen; at 60 ℃; for 20h; under 7500.75 Torr; Autoclave;

With hydrogenchloride; In diethyl ether;

DOI:10.1002/cssc.202100553

Reference yield: 93.0%

C9H8F3N*ClH (1164111-43-6) → (R)-1-(4-(trifluoromethyl)phenyl)ethanamine hydrochloride (856645-99-3)

Guidance literature:

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1,1'-bis[(S)-4,5-dihydro-3H-binaphtho[2,1-c:1',2'-e]phosphino]ferrocene; hydrogen; In methanol; dichloromethane; at 20 ℃; for 20h; under 7600.51 Torr; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ja903319r

Reference yield: 89.0%

(RS)-2-methyl-N-((R)-1-(4-trifluoromethylphenyl)ethyl)propane-2-sulfinamide (911372-68-4) → (R)-1-(4-(trifluoromethyl)phenyl)ethanamine hydrochloride (856645-99-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

DOI:10.1021/jo0609834

upstream raw materials:

(R_S)-2-methyl-N-((S)-1-(4-trifluoromethylphenyl)ethyl)propane-2-sulfinamide

(R_S)-2-methyl-N-(1-(4-trifluoromethylphenyl)ethylidene)propane-2-sulfinamide

1-(4-trifluoromethylphenyl)ethanone

4-trifluoromethylphenylacetylene

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