Spiro[2H-1-benzopyran-2,4'-piperidin]-4(3H)-one, 1'-(1H-indazol-7-ylcarbonyl)-6,7-diMethyl-

Base Information

• Chemical Name: Spiro[2H-1-benzopyran-2,4'-piperidin]-4(3H)-one, 1'-(1H-indazol-7-ylcarbonyl)-6,7-diMethyl-
• CAS No.: 1031413-43-0
• Molecular Formula: C23H23N3O3
• Molecular Weight: 389.44702
• Hs Code.: 2933998090
• Mol file: 1031413-43-0.mol

Synonyms:Spiro[2H-1-benzopyran-2,4'-piperidin]-4(3H)-one, 1'-(1H-indazol-7-ylcarbonyl)-6,7-diMethyl-;1'-(1H-Indazole-7-carbonyl)-6,7-dimethylspiro[chroman-2,4'-piperidin]-4-one

Chemical Property of Spiro[2H-1-benzopyran-2,4'-piperidin]-4(3H)-one, 1'-(1H-indazol-7-ylcarbonyl)-6,7-diMethyl-

Chemical Property:

• PSA: 75.29000
• LogP: 3.75780

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Spiro[2H-1-benzopyran-2,4'-piperidin]-4(3H)-one, 1'-(1H-indazol-7-ylcarbonyl)-6,7-diMethyl-

There total 9 articles about Spiro[2H-1-benzopyran-2,4'-piperidin]-4(3H)-one, 1'-(1H-indazol-7-ylcarbonyl)-6,7-diMethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1H-indazole-7-carboxylic acid (677304-69-7) + 6,7-dimethylspiro[chromene-2,4-piperidin]-4(3H)-one (927978-38-9) → 1'-(1H-indazol-7-ylcarbonyl)-6,7-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one (1031413-43-0)

Guidance literature:

With triethylamine; HATU; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

1H-indazole-7-carboxylic acid (677304-69-7) + 2-acetyl-4,5-dimethylphenol (36436-65-4) + N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → 1'-(1H-indazol-7-ylcarbonyl)-6,7-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one (1031413-43-0)

Guidance literature:

2-acetyl-4,5-dimethylphenol; N-tert-butyloxycarbonylpiperidin-4-one; With pyrrolidine; In toluene;

With hydrogenchloride; In 1,4-dioxane;

1H-indazole-7-carboxylic acid;

DOI:10.1016/j.bmcl.2009.04.091

Reference yield:

1H-indazole-7-carboxylic acid methyl ester (755752-82-0,952479-65-1) → 1'-(1H-indazol-7-ylcarbonyl)-6,7-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one (1031413-43-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydroxide; water / methanol / 0 - 20 °C / Heating / reflux

1.2: pH 5.5

2.1: triethylamine; HATU / dichloromethane / 16 h / 20 °C

With potassium hydroxide; water; triethylamine; HATU; In methanol; dichloromethane;

upstream raw materials:

1H-indazole-7-carboxylic acid

6,7-dimethylspiro[chromene-2,4-piperidin]-4(3H)-one

2-acetyl-4,5-dimethylphenol

N-tert-butyloxycarbonylpiperidin-4-one