(S)-2-(BENZYLOXYCARBONYLAMINO)-2-PHENYLPROPANOIC ACID

Base Information

Chemical Name:(S)-2-(BENZYLOXYCARBONYLAMINO)-2-PHENYLPROPANOIC ACID
CAS No.:169738-78-7
Molecular Formula:C17H17NO4
Molecular Weight:299.32
Hs Code.:
Mol file:169738-78-7.mol

Synonyms:(S)-2-(BENZYLOXYCARBONYLAMINO)-2-PHENYLPROPANOIC ACID;(S)-CBZ-ALPHA-METHYL-PHENYLGLYCINE

Suppliers and Price of (S)-2-(BENZYLOXYCARBONYLAMINO)-2-PHENYLPROPANOIC ACID

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (S)-2-(BENZYLOXYCARBONYLAMINO)-2-PHENYLPROPANOIC ACID

Chemical Property:

Boiling Point:501.1±50.0 °C(Predicted)
PKA:3.54±0.10(Predicted)
PSA：75.63000
Density:1.245±0.06 g/cm3(Predicted)
LogP:3.30370

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-2-(BENZYLOXYCARBONYLAMINO)-2-PHENYLPROPANOIC ACID

There total 4 articles about (S)-2-(BENZYLOXYCARBONYLAMINO)-2-PHENYLPROPANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 13139-17-8
N-(Benzyloxycarbonyloxy)succinimide

: 13398-26-0,6945-32-0
(S)-2-methyl-2-phenylglycine

: 169738-78-7
(S)-N²-<(benzyloxy)carbonyl>-2-methyl-2-phenylglycine

Guidance literature:: With sodium hydroxide; sodium hydrogencarbonate; In 1,4-dioxane; at 20 ℃; for 384h;
DOI:10.1016/j.tetasy.2004.04.044

Reference yield: 80.0%

: (4S,5S)-4-[(S)-(1-N-(benzoyloxycarbonylamino-1-phenyl)ethyl)]-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane

: 169738-78-7
(S)-N²-<(benzyloxy)carbonyl>-2-methyl-2-phenylglycine

Guidance literature:: (4S,5S)-4-[(S)-(1-N-(benzoyloxycarbonylamino-1-phenyl)ethyl)]-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane; With toluene-4-sulfonic acid; In methanol; at 60 ℃; for 12h;

With sodium periodate; In tetrahydrofuran; water; at 20 ℃; for 8h;

With potassium permanganate; sodium dihydrogenphosphate; In tert-butyl alcohol; at 20 ℃; for 0.166667h;
DOI:10.1016/S0040-4020(98)00503-1

Reference yield:

: (4S,5S)-4-[(S)-(1-amino-1-phenyl)ethyl]-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane

: 169738-78-7
(S)-N²-<(benzyloxy)carbonyl>-2-methyl-2-phenylglycine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 95 percent / Diisopropylethylamine / acetonitrile / 20 °C / TLC-monitoring

2.1: TsOH / methanol / 12 h / 60 °C

2.2: NaIO₄ / tetrahydrofuran; H₂O / 8 h / 20 °C

2.3: 80 percent / KMnO₄; NaH₂PO₄ / 2-methyl-propan-2-ol / 0.17 h / 20 °C

With toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In methanol; acetonitrile; 1.1: Acylation / 2.1: Ring cleavage / 2.2: Oxidation / 2.3: Oxidation;
DOI:10.1016/S0040-4020(98)00503-1