5-Bromo-2-(2-hydroxyethylaminoacetylamino)-2'-fluorobenzophenone

Base Information

Chemical Name:5-Bromo-2-(2-hydroxyethylaminoacetylamino)-2'-fluorobenzophenone
CAS No.:71980-88-6
Molecular Formula:C₁₇H₁₆BrFN₂O₃
Molecular Weight:395.228
Hs Code.:
DSSTox Substance ID:DTXSID40519828
Nikkaji Number:J23.033B
Wikidata:Q82383300
Mol file:71980-88-6.mol

Synonyms:71980-88-6;5-Bromo-2-(2-hydroxyethylaminoacetylamino)-2'-fluorobenzophenone;N-[4-bromo-2-(2-fluorobenzoyl)phenyl]-2-(2-hydroxyethylamino)acetamide;DTXSID40519828;2-(2-hydroxyethylamino)acetamido-5-bromo-2'-fluorobenzophenone;N-[4-Bromo-2-(2-fluorobenzoyl)phenyl]-N~2~-(2-hydroxyethyl)glycinamide

Suppliers and Price of 5-Bromo-2-(2-hydroxyethylaminoacetylamino)-2'-fluorobenzophenone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-[4-Bromo-2-(2-fluorobenzoyl)phenyl]-2-[(2-hydroxyethyl)amino]acetamide
25mg
$ 185.00

TRC
N-[4-Bromo-2-(2-fluorobenzoyl)phenyl]-2-[(2-hydroxyethyl)amino]acetamide
5mg
$ 55.00

Total 4 raw suppliers

Chemical Property of 5-Bromo-2-(2-hydroxyethylaminoacetylamino)-2'-fluorobenzophenone

Chemical Property:

PSA：81.92000
LogP:3.38000
XLogP3:2.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:394.03283
Heavy Atom Count:24
Complexity:438

Purity/Quality:

99% ^*data from raw suppliers

N-[4-Bromo-2-(2-fluorobenzoyl)phenyl]-2-[(2-hydroxyethyl)amino]acetamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C(=O)C2=C(C=CC(=C2)Br)NC(=O)CNCCO)F
Uses N-[4-Bromo-2-(2-fluorobenzoyl)phenyl]-2-[(2-hydroxyethyl)amino]acetamide is an intermediate used in the synthesis of Haloxazolam (H104000), which is a sleep-inducing agent, related structurally to Oxazolam and Cloxazolam (C587475). It is a sedative, hypnotic and controlled substance (depressant).

Technology Process of 5-Bromo-2-(2-hydroxyethylaminoacetylamino)-2'-fluorobenzophenone

There total 3 articles about 5-Bromo-2-(2-hydroxyethylaminoacetylamino)-2'-fluorobenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 121179-88-2
7-Bromo-5-(2-fluoro-phenyl)-4-(2-hydroxy-ethyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4-ium

: 71980-88-6
N-<4-bromo-2-(2-fluorobenzoyl)>phenyl-2-(2-hydroxyethyl)aminoacetamide

Guidance literature:: With hydrogenchloride; In 1,2-dimethoxyethane; water; at 22 ℃; Rate constant; half-life time; pH-dependence;

Reference yield:

: 59128-97-1,88195-91-9,88195-92-0
10-bromo-11b-(o-fluorophenyl)-2,3,7,11b-tetrahydro-oxazolo<3,2-d><1,4>benzodiazepin-6(5H)-one

: 71980-88-6
N-<4-bromo-2-(2-fluorobenzoyl)>phenyl-2-(2-hydroxyethyl)aminoacetamide

: 121179-88-2
7-Bromo-5-(2-fluoro-phenyl)-4-(2-hydroxy-ethyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4-ium

Guidance literature:: With hydrogenchloride; In 1,2-dimethoxyethane; water; at 22 ℃; Rate constant; Mechanism;

Reference yield:

: 59128-97-1,88195-91-9,88195-92-0
10-bromo-11b-(o-fluorophenyl)-2,3,7,11b-tetrahydro-oxazolo<3,2-d><1,4>benzodiazepin-6(5H)-one

: 71980-88-6
N-<4-bromo-2-(2-fluorobenzoyl)>phenyl-2-(2-hydroxyethyl)aminoacetamide

Guidance literature:: With water; at 25 ℃; Thermodynamic data; Rate constant; pH and temperature dependence of hydrolysis rate;
DOI:10.1248/cpb.34.320