1-[[(1,1-dimethylethoxy)carbonyl]amino]cyclopropaneacetic acid

Base Information

• Chemical Name: 1-[[(1,1-dimethylethoxy)carbonyl]amino]cyclopropaneacetic acid
• CAS No.: 1463522-68-0
• Molecular Weight: 215.25
• Mol file: 1463522-68-0.mol

Synonyms:1-[[(1,1-dimethylethoxy)carbonyl]amino]cyclopropaneacetic acid;2-(1-{[(tert-butoxy)carbonyl]amino}cyclopropyl)acetic acid

Chemical Property of 1-[[(1,1-dimethylethoxy)carbonyl]amino]cyclopropaneacetic acid

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

2-(1-((tert-butoxycarbonyl)amino)cyclopropyl)aceticacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[[(1,1-dimethylethoxy)carbonyl]amino]cyclopropaneacetic acid

There total 5 articles about 1-[[(1,1-dimethylethoxy)carbonyl]amino]cyclopropaneacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

tert-butyl N-[1-(2-hydroxyethyl)cyclopropyl]carbamate (753023-57-3) → 2-(1-(tert-butoxycarbonylamino)cyclopropyl)acetic acid (1463522-68-0)

Guidance literature:

With sodium periodate; ruthenium(III) trichloride hydrate; water; In dichloromethane; acetonitrile; at 20 ℃; for 3h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 2-(1-aminocyclopropyl)acetic acid (133616-20-3) → 2-(1-(tert-butoxycarbonylamino)cyclopropyl)acetic acid (1463522-68-0)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; at 20 ℃; for 24h;

DOI:10.1016/j.bmcl.2014.01.017

Reference yield:

1-(2-((tert-butyldimethylsilyl)oxy)-ethyl)cyclopropan-1-amine → 2-(1-(tert-butoxycarbonylamino)cyclopropyl)acetic acid (1463522-68-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydrogencarbonate; water / tetrahydrofuran / 17 h / 20 °C

2: triethylamine tris(hydrogen fluoride) / dichloromethane / 17 h / 20 °C

3: ruthenium(III) trichloride hydrate; sodium periodate; water / dichloromethane; acetonitrile / 3 h / 20 °C

With sodium periodate; ruthenium(III) trichloride hydrate; water; sodium hydrogencarbonate; triethylamine tris(hydrogen fluoride); In tetrahydrofuran; dichloromethane; acetonitrile;

upstream raw materials:

tert-butyl N-[1-(2-hydroxyethyl)cyclopropyl]carbamate

di-tert-butyl dicarbonate

2-(1-aminocyclopropyl)acetic acid

1-[2-(benzyloxy)ethyl]cyclopropan-1-amine

Downstream raw materials:

C₂₂H₂₉ClN₂O₃S