(R)-5-hydroxy-2-aminovaleric acid

Base Information

• Chemical Name: (R)-5-hydroxy-2-aminovaleric acid
• CAS No.: 6152-90-5
• Molecular Formula: C5H11NO3
• Molecular Weight: 133.15
• Mol file: 6152-90-5.mol

Synonyms:(R)-5-hydroxy-2-aminovaleric acid

Chemical Property of (R)-5-hydroxy-2-aminovaleric acid

Chemical Property:

• Boiling Point: 306.1±37.0 °C(Predicted)
• PKA: 2.51±0.24(Predicted)
• PSA: 83.55000
• Density: 1.241±0.06 g/cm3(Predicted)
• LogP: -0.12890

Purity/Quality:

97% ^*data from raw suppliers

D-DELTA-HYDROXYNORVALINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-5-hydroxy-2-aminovaleric acid

There total 5 articles about (R)-5-hydroxy-2-aminovaleric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

N-trityl-δ-hydroxynorvaline diethylammonium salt → (R)-5-hydroxy-2-aminovaleric acid (6152-90-5)

Guidance literature:

In acetic acid; Ambient temperature;

DOI:10.1039/c39870001583

Reference yield: 81.0%

tert-butyl (2R)-5-hydroxy-2-(N-(9-(9-phenylfluorenyl))amino)pentanoate → (R)-5-hydroxy-2-aminovaleric acid (6152-90-5)

Guidance literature:

tert-butyl (2R)-5-hydroxy-2-(N-(9-(9-phenylfluorenyl))amino)pentanoate; With trifluoroacetic acid; In dichloromethane; at 20 ℃;

With Dowex-50W resin [H(+)-form]; In water; Further stages.;

DOI:10.1021/jo026479q

Reference yield:

Boc-D-pentahomoserine → (R)-5-hydroxy-2-aminovaleric acid (6152-90-5)

Guidance literature:

With formic acid; at 20 ℃; for 4h;

DOI:10.1021/np800631t

upstream raw materials:

(R)-2-amino-5-methoxy-5-oxopentanoic acid

Refernces

• 1、 Luesch, Hendrik,Hoffmann, Dietmar,Hevel, Joan M.,Becker, Julia E.,Golakoti, Trimurtulu,Moore, Richard E.. "Biosynthesis of 4-methylproline in cyanobacteria: Cloning of nosE and nosF genes and biochemical characterization of the encoded dehydrogenase and reductase activities". . p. 83 - 91. Retrieved 2007/10/03.