1-(1-Aminoethyl)adamantan-2-ol

Base Information

Chemical Name:1-(1-Aminoethyl)adamantan-2-ol
CAS No.:127619-49-2
Molecular Formula:C₁₂H₂₁NO
Molecular Weight:195.305
Hs Code.:
DSSTox Substance ID:DTXSID30436434
ChEMBL ID:CHEMBL294248
Mol file:127619-49-2.mol

Synonyms:1-(1-aminoethyl)adamantan-2-ol;127619-49-2;2-(alpha,beta)-Hydroxy rimantadine;2-(|A,|A)-Hydroxy Rimantadine;CHEMBL294248;DTXSID30436434;FT-0670104

Suppliers and Price of 1-(1-Aminoethyl)adamantan-2-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 1-(1-Aminoethyl)adamantan-2-ol

Chemical Property:

PSA：46.25000
LogP:2.22110
XLogP3:1.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:195.162314293
Heavy Atom Count:14
Complexity:239

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C12CC3CC(C1)CC(C3)C2O)N

Technology Process of 1-(1-Aminoethyl)adamantan-2-ol

There total 4 articles about 1-(1-Aminoethyl)adamantan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 127619-47-0
1-acetyl-2-adamantanol oxime

: 127619-49-2,133908-81-3,133963-63-0
1-(1-aminoethyl)-2-adamantanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; 1.) reflux, 4 h, 2.) RT, 16 h;
DOI:10.1021/jm00169a029

Reference yield:

: 40556-86-3
2-oxoadamantane-1-carboxylic acid

: 127619-49-2,133908-81-3,133963-63-0
1-(1-aminoethyl)-2-adamantanol

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / NaBH₄ / dimethylformamide / 0 - 20 °C

3: 94 percent / hydroxylamine hydrochloride, pyridine / ethanol / 2 h / Heating

4: 1.41 g / LiAlH₄ / tetrahydrofuran; diethyl ether / 1.) reflux, 4 h, 2.) RT, 16 h

With pyridine; sodium tetrahydroborate; lithium aluminium tetrahydride; hydroxylamine hydrochloride; In tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00169a029

Reference yield:

: 40556-88-5
1-carboxy-2-adamantanol

: 127619-49-2,133908-81-3,133963-63-0
1-(1-aminoethyl)-2-adamantanol

Guidance literature:: Multi-step reaction with 3 steps

2: 94 percent / hydroxylamine hydrochloride, pyridine / ethanol / 2 h / Heating

3: 1.41 g / LiAlH₄ / tetrahydrofuran; diethyl ether / 1.) reflux, 4 h, 2.) RT, 16 h

With pyridine; lithium aluminium tetrahydride; hydroxylamine hydrochloride; In tetrahydrofuran; diethyl ether; ethanol;
DOI:10.1021/jm00169a029