(2R,2'R)-2,2'-Bipyrrolidine

Base Information

• Chemical Name: (2R,2'R)-2,2'-Bipyrrolidine
• CAS No.: 107886-22-6
• Molecular Formula: C₈H₁₆N₂
• Molecular Weight: 140.228
• Mol file: 107886-22-6.mol

Synonyms:(2R,2'R)-2,2'-Bipyrrolidine;(2R,2'R)-Octahydro-2,2'-bi[1H-pyrrole];[2R,2'R,(-)]-Octahydro-2,2'-bi[1H-pyrrole];2,2'-Bi[(2R)-pyrrolidine];2,2'-Bi[(R)-pyrrolidine];(2R,2'R)-(-)-2,2'-Bipyrrolidine,99%

Chemical Property of (2R,2'R)-2,2'-Bipyrrolidine

Chemical Property:

• PSA: 24.06000
• LogP: 1.14800

Purity/Quality:

95% ^*data from raw suppliers

(2R,2′R)-2,2′-Bipyrrolidine ≥99.0% (GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2R,2'R)-2,2'-Bipyrrolidine

There total 5 articles about (2R,2'R)-2,2'-Bipyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(±)-1,1'-([2,2'-bipyrrolidine]-1,1'-diyl)bis(2,2,2-trifluoroethan-1-one) → 2,2'-bipyrrolidine (74295-58-2,107886-07-7,107886-22-6,124779-66-4,137037-20-8)

Guidance literature:

With potassium hydroxide; In methanol; at 23 ℃; for 4h; Inert atmosphere;

DOI:10.1021/acs.orglett.7b01768

Reference yield: 83.0%

dl-1,1'-dibenzoyl-2,2'-bipyrrolidine (136937-01-4,136937-02-5) → 2,2'-bipyrrolidine (74295-58-2,107886-07-7,107886-22-6,124779-66-4,137037-20-8)

Guidance literature:

With hydrogenchloride; for 48h; Heating;

DOI:10.1055/s-1991-26576

Reference yield:

2-(3,4-dihydro-2H-pyrrol-5-yl)pyrrole (10087-65-7) → 2,2'-bipyrrolidine (74295-58-2,107886-07-7,107886-22-6,124779-66-4,137037-20-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / H₂ / Rh/Al₂O₃ / acetic acid; methanol / 120 h / 2250.2 - 3750.3 Torr / Ambient temperature

2: 45 percent / triethylamine / CH₂Cl₂ / 1 h / 0 °C

3: 83 percent / conc. HCl / 48 h / Heating

With hydrogenchloride; hydrogen; triethylamine; Rh/Al₂O₃; In methanol; dichloromethane; acetic acid;

DOI:10.1055/s-1991-26576

upstream raw materials:

dl-1,1'-dibenzoyl-2,2'-bipyrrolidine

2,2’-bipyrrolidine

2-(3,4-dihydro-2H-pyrrol-5-yl)pyrrole