[S,(+)]-DOB

Base Information

• Chemical Name: [S,(+)]-DOB
• CAS No.: 43061-16-1
• Molecular Formula: C11H16BrNO2
• Molecular Weight: 274.15
• Mol file: 43061-16-1.mol

Synonyms:(S)-1-(2,5-Dimethoxy-4-bromophenyl)-2-aminopropane;(S)-4-Bromo-2,5-dimethoxy-α-methylbenzeneethanamine;[S,(+)]-DOB

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Chemical Property of [S,(+)]-DOB

Chemical Property:

• PSA: 44.48000
• LogP: 3.05630

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [S,(+)]-DOB

There total 4 articles about [S,(+)]-DOB which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(S)-2-(2,5-Dimethoxy-phenyl)-1-methyl-ethyl]-((S)-1-phenyl-ethyl)-amine; hydrochloride → (+)-Brolamfetamine (43061-16-1)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd-C / methanol; H₂O

2: Br₂ / acetic acid

With hydrogen; bromine; palladium on activated charcoal; In methanol; water; acetic acid;

DOI:10.1021/jm00263a013

Reference yield:

(S)-2-(2,5-dimethoxy-phenyl)-1-methyl-ethylamine (58993-80-9) → (+)-Brolamfetamine (43061-16-1)

Guidance literature:

With hydrogen bromide; bromine; In acetic acid;

DOI:10.1021/jm00256a016

Reference yield:

{(R)-1-[(S)-2-(2,5-Dimethoxy-phenyl)-1-methyl-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester → (+)-Brolamfetamine (43061-16-1)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) H₂, Pd-C, (ii) PhNCS, (iii) CF₃CO₂H

2: Br₂, HBr / acetic acid

With hydrogen bromide; bromine; In acetic acid;

DOI:10.1021/jm00256a016

upstream raw materials:

(S)-2-(2,5-dimethoxy-phenyl)-1-methyl-ethylamine