methyl 2-(3-chloro-4-(dimethylcarbamothioyloxy)phenyl)acetate

Base Information

• Chemical Name: methyl 2-(3-chloro-4-(dimethylcarbamothioyloxy)phenyl)acetate
• CAS No.: 91373-91-0
• Molecular Formula: C₁₂H₁₄ClNO₃S
• Molecular Weight: 287.767
• Mol file: 91373-91-0.mol

Synonyms:methyl 2-(3-chloro-4-(dimethylcarbamothioyloxy)phenyl)acetate

Chemical Property of methyl 2-(3-chloro-4-(dimethylcarbamothioyloxy)phenyl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of methyl 2-(3-chloro-4-(dimethylcarbamothioyloxy)phenyl)acetate

There total 3 articles about methyl 2-(3-chloro-4-(dimethylcarbamothioyloxy)phenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methyl 3-chloro-4-hydroxyphenylacetate (57017-95-5) + N,N-Dimethylthiocarbamoyl chloride (16420-13-6) → (3-chloro-4-dimethylthiocarbamoyloxyphenyl)acetic acid methyl ester (91373-91-0)

Guidance literature:

With pyridine; for 4h; Heating;

DOI:10.1016/S0960-894X(03)00115-X

Reference yield:

(3-chloro-4-hydroxy-phenyl)-acetic acid (33697-81-3) → (3-chloro-4-dimethylthiocarbamoyloxyphenyl)acetic acid methyl ester (91373-91-0)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂SO₄ / Heating

2: Et₃N; DMAP / dioxane / 16 h / Heating

With dmap; sulfuric acid; triethylamine; In 1,4-dioxane;

DOI:10.1016/j.bmcl.2006.02.079

Reference yield:

N,N-Dimethylthiocarbamoyl chloride (16420-13-6) + (4-acetoxy-3-chloro-phenyl)-acetic acid methyl ester → (3-chloro-4-dimethylthiocarbamoyloxyphenyl)acetic acid methyl ester (91373-91-0)

Guidance literature:

With dmap; triethylamine; In 1,4-dioxane; for 4h; Heating;

DOI:10.1016/S0960-894X(01)00596-0

upstream raw materials:

N,N-Dimethylthiocarbamoyl chloride

methyl 3-chloro-4-hydroxyphenylacetate

(3-chloro-4-hydroxy-phenyl)-acetic acid

Downstream raw materials:

[3-chloro-4-(3,5-dibromobenzylsulfanyl)phenyl]acetic acid methyl ester

[4-(4,4''-bis-trifluoromethyl-[1,1';3',1'']terphenyl-5'-ylmethylsulfanyl)-3-chloro-phenyl]-acetic acid methyl ester

3-chloro-4-sulphanyl-phenylacetic acid methyl ester

3-chloro-4-[2-[[(1,1-dimethylethoxy)carbonyl]-amino]-ethylthio]benzeneacetic acid methyl ester