Androst-5-ene-3β,19-diol 3-acetate

Base Information

• Chemical Name: Androst-5-ene-3β,19-diol 3-acetate
• CAS No.: 55320-48-4
• Molecular Formula: C₂₁H₃₂O₃
• Molecular Weight: 332.483
• Mol file: 55320-48-4.mol

Synonyms:Androst-5-ene-3β,19-diol 3-acetate

Chemical Property of Androst-5-ene-3β,19-diol 3-acetate

Chemical Property:

• Melting Point: 170 - 172 °C
• PSA: 46.53000
• LogP: 4.24340

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Androst-5-ene-3β,19-diol 3-acetate

There total 4 articles about Androst-5-ene-3β,19-diol 3-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3β-acetoxyandrost-5-ene (13067-44-2) → 3β-Acetoxy-19-hydroxy-androsten-(5) (55320-48-4)

Guidance literature:

Multi-step reaction with 2 steps

1: NBS, aq. HClO₄

2: (i) I₂, Pb(OAc)4, (ii) Zn

With N-Bromosuccinimide; perchloric acid;

DOI:10.1021/ja00452a041

Reference yield:

17,17-Ethylendimercapto-3β-acetoxyandrosten-5-ol-19 (107421-95-4) → 3β-Acetoxy-19-hydroxy-androsten-(5) (55320-48-4)

Guidance literature:

nickel; In ethanol; Heating;

DOI:10.1016/S0039-128X(63)80017-3

Reference yield:

3β-acetoxy-5α-bromo-androstane-6β-ol (59477-06-4) → 3β-Acetoxy-19-hydroxy-androsten-(5) (55320-48-4)

Guidance literature:

Multistep reaction; (i) I₂, Pb(OAc)4, (ii) Zn;

DOI:10.1021/ja00452a041

upstream raw materials:

17,17-Ethylendimercapto-3β-acetoxyandrosten-5-ol-19

3β-acetoxy-5α-bromo-androstane-6β-ol

3β-acetoxyandrost-5-ene

Downstream raw materials:

Androst-5-en-3β-ol-benzoat-19-d