Chemical Property of TA-01
Chemical Property:
- Boiling Point:511.1±50.0 °C(Predicted)
- PKA:9.26±0.24(Predicted)
- PSA：41.57000
- Density:1.337±0.06 g/cm3(Predicted)
- LogP:5.22300
- Purity/Quality:
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99%, *data from raw suppliers
TA01 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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Useful:
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Description
TA-01 is a derivative of the p38 MAPK inhibitor SB 203580 (Item Nos. 13067 | 13344) and an inducer of cardiomyocyte differentiation. It is cardiomyogenic at concentrations less than 5 μM, increasing expression of the cardiomyocyte marker NKX2-5 by 2.2-fold and decreasing expression of mesoderm markers and the pre-cardiac marker Isl-1 in HES-3 NKX2-5eGFP/w cells when applied after embryoid body formation. TA-01 inhibits casein kinase 1ε (CK1ε) and CK1Δ and reduces expression of Wnt/β-catenin signaling pathway members, activities that positively correlate with its cardiomyogenic activity.
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Uses
TA 01 induces cardiomyocyte differentiation of pluripotent stem cells.
