2-Demethyl Colchicine

Base Information

• Chemical Name: 2-Demethyl Colchicine
• CAS No.: 102491-80-5
• Molecular Formula: C₂₁H₂₃NO₆
• Molecular Weight: 385.417
• Mol file: 102491-80-5.mol

Synonyms:N-[(7S)-5,6,7,9-Tetrahydro-2-hydroxy-1,3,10-trimethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide;NSC 18053;O2-Demethylcolchicine;NSC 180533

Chemical Property of 2-Demethyl Colchicine

Chemical Property:

• Vapor Pressure: 2.63E-24mmHg at 25°C
• Melting Point: 166-168°C
• Boiling Point: 766.1°C at 760 mmHg
• Flash Point: 417.1°C
• PSA: 94.09000
• Density: 1.31g/cm³
• LogP: 2.95950
• Storage Temp.: -20°C Freezer

Purity/Quality:

97% ^*data from raw suppliers

2-DemethylColchicine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A metabolite of Colchicine. Has shown anti-tumor activity A metabolite of Colchicine (C640000). Has shown anti-tumor activity.

Technology Process of 2-Demethyl Colchicine

There total 2 articles about 2-Demethyl Colchicine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl) acetamide (209810-38-8,54192-66-4) → 2-Demethyl-colchicin (102491-80-5)

Guidance literature:

With sulfuric acid; In acetic acid; at 55 ℃; for 4h;

DOI:10.1021/jo00363a021

Reference yield:

→ 2-Demethyl-colchicin (102491-80-5)

Guidance literature:

Colchicin, Fe²⁺ oder Cu²⁺, O2, Ascorbat;

upstream raw materials:

N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl) acetamide

Refernces