Chemical Property of N-[4-[(1H-imidazol-5-ylmethyl)amino]-2-(1-naphthalenyl)benzoyl]-L-leucine,2,2,2-trifluoroacetatesalt
Chemical Property:
- Melting Point:103-118.5 °C
- PSA：107.11000
- LogP:5.53500
- Storage Temp.:−20°C
- Solubility.:DMSO: 25 mg/mL
- Hydrogen Bond Donor Count:5
- Hydrogen Bond Acceptor Count:10
- Rotatable Bond Count:9
- Exact Mass:570.20900452
- Heavy Atom Count:41
- Complexity:770
- Purity/Quality:
-
97% *data from raw suppliers
GGTI-2133 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:Xi
- Statements:
36/37/38
- Safety Statements:
26-36
- MSDS Files:
-
Useful:
- Canonical SMILES:CC(C)CC(C(=O)O)NC(=O)C1=C(C=C(C=C1)NCC2=CN=CN2)C3=CC=CC4=CC=CC=C43.C(=O)(C(F)(F)F)O
- Isomeric SMILES:CC(C)C[C@@H](C(=O)O)NC(=O)C1=C(C=C(C=C1)NCC2=CN=CN2)C3=CC=CC4=CC=CC=C43.C(=O)(C(F)(F)F)O
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Uses
GGTI-2133 i an inhibitors of protein geranylgeranyltransferase-I. Increases prelamin A accumulation by inhibiting ZMPSTE24 protein in human fibroblast. GGTI-2133 inhibited proliferation and migration via involvement of RhoA and RalB proteins in human oral squamous cell carcinoma cell.
