(R)-3-BROMO-4-HYDROXYPHENYLGLYCINE

Base Information

• Chemical Name: (R)-3-BROMO-4-HYDROXYPHENYLGLYCINE
• CAS No.: 139517-61-6
• Molecular Formula: C8H8BrNO3
• Molecular Weight: 246.059
• Mol file: 139517-61-6.mol

Synonyms:(R)-3-BROMO-4-HYDROXYPHENYLGLYCINE

Chemical Property of (R)-3-BROMO-4-HYDROXYPHENYLGLYCINE

Chemical Property:

• PSA: 83.55000
• LogP: 1.93940

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-BROMO-4-HYDROXYPHENYLGLYCINE

There total 1 articles about (R)-3-BROMO-4-HYDROXYPHENYLGLYCINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

D-4-hydroxyphenylglycine (22818-40-2) → (R)-3-bromo-4-hydroxyphenylglycine (139517-61-6)

Guidance literature:

With hydrogen bromide; bromine; In acetic acid; Ambient temperature;

Reference yield:

(R)-3-bromo-4-hydroxyphenylglycine (139517-61-6) → methyl (2R)-2-(3-bromo-4-hydroxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]acetate (162458-72-2)

Guidance literature:

Multi-step reaction with 2 steps

1: AcCl

2: NaHCO₃ / CH₂Cl₂

With sodium hydrogencarbonate; acetyl chloride; In dichloromethane;

DOI:10.1016/S0040-4039(99)00557-2

Reference yield:

(R)-3-bromo-4-hydroxyphenylglycine (139517-61-6) → [(R)-1-(3-Bromo-4-hydroxy-phenyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester (162458-76-6)

Guidance literature:

Multi-step reaction with 3 steps

1: AcCl

2: NaHCO₃ / CH₂Cl₂

3: 93 percent / LiClO₄, NaBH₄ / tetrahydrofuran

With sodium tetrahydroborate; lithium perchlorate; sodium hydrogencarbonate; acetyl chloride; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0040-4039(99)00557-2

upstream raw materials:

D-4-hydroxyphenylglycine

Downstream raw materials:

[(R)-1-(3-Bromo-4-hydroxy-phenyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester

methyl (2R)-2-(3-bromo-4-hydroxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]acetate

(R)-4-(3-Bromo-4-hydroxy-phenyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

(R)-4-[4-((1R,2S)-3-Benzyloxy-1-benzyloxymethyl-2-hydroxy-propoxy)-3-bromo-phenyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester