Boc-D-aspartinol 4-Benzyl Ester

Base Information

• Chemical Name: Boc-D-aspartinol 4-Benzyl Ester
• CAS No.: 182748-72-7
• Molecular Formula: C16H23NO5
• Molecular Weight: 309.362
• Mol file: 182748-72-7.mol

Synonyms:Boc-D-aspartinol 4-Benzyl Ester;benzyl(R)-3-((tert-butoxycarbonyl)amino)-4-hydroxybutanoate

Chemical Property of Boc-D-aspartinol 4-Benzyl Ester

Chemical Property:

• PSA: 84.86000
• LogP: 2.39640
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(R)-Benzyl3-((tert-butoxycarbonyl)amino)-4-hydroxybutanoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Boc-D-aspartinol 4-Benzyl Ester

There total 6 articles about Boc-D-aspartinol 4-Benzyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-benzyl Boc-D-aspartate (51186-58-4,98482-77-0) → (R)-3-((tert-butoxycarbonyl)amino)-4-hydroxybutyric acid benzyl ester (182748-72-7)

Guidance literature:

4-benzyl Boc-D-aspartate; With 4-methyl-morpholine; isobutyl chloroformate; In 1,2-dimethoxyethane; at -10 ℃; for 0.166667h;

With sodium tetrahydroborate; In 1,2-dimethoxyethane; water;

DOI:10.1016/j.tetasy.2008.12.022

Reference yield: 89.0%

(R)-3-tert-Butoxycarbonylamino-4-carboxyoxy-4-oxo-butyric acid benzyl ester → (R)-3-((tert-butoxycarbonyl)amino)-4-hydroxybutyric acid benzyl ester (182748-72-7)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran;

DOI:10.1016/0040-4039(96)01515-8

Reference yield:

3-tert-butoxycarbonylamino-4-ethoxycarbonyloxy-4-oxo-butyric acid benzyl ester → (R)-3-((tert-butoxycarbonyl)amino)-4-hydroxybutyric acid benzyl ester (182748-72-7)

Guidance literature:

With sodium tetrahydroborate;

DOI:10.1016/S0960-894X(03)00075-1

upstream raw materials:

4-benzyl Boc-D-aspartate

Downstream raw materials:

(R)-3-amino-4-hydroxybutanoic acid hydrochloride

(R)-3-tert-Butoxycarbonylamino-4-(4-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-butyric acid benzyl ester

benzyl (3R)-3-tert-butoxycarbonylamino-4-(3-cyanophenoxy)butyrate

Boc-Asp(β-OBzl)ψ[CH2N(o-NBS)]Gly(OAll)

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