3a-Methyl-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinoline

Base Information

• Chemical Name: 3a-Methyl-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinoline
• CAS No.: 201541-31-3
• Molecular Formula: C₁₃H₁₇N
• Molecular Weight: 187.285
• Mol file: 201541-31-3.mol

Synonyms:3a-Methyl-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinoline;1,2,3,3a,4,5-Hexahydro-3a-methylpyrrolo[1,2-a]quinoline;5,6,6a,10-Tetrahydro-6a-methylpyrrolidino[1,2-a]quinoline

Chemical Property of 3a-Methyl-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinoline

Chemical Property:

• Boiling Point: 295℃
• Flash Point: 120℃
• PSA: 3.24000
• Density: 1.07
• LogP: 3.05670

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3a-Methyl-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinoline

There total 5 articles about 3a-Methyl-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3a-Methyl-1,2,3,3a-tetrahydro-pyrrolo[1,2-a]quinoline (201541-30-2) → 3a-Methyl-1,2,3,3a,4,5-hexahydro-pyrrolo[1,2-a]quinoline (201541-31-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; ethyl acetate; for 4h; Yield given;

DOI:10.1021/jm970699s

Reference yield:

5-chloro-2-pentanone (5891-21-4) → 3a-Methyl-1,2,3,3a,4,5-hexahydro-pyrrolo[1,2-a]quinoline (201541-31-3)

Guidance literature:

Multi-step reaction with 5 steps

1: tetrahydrofuran / 1 h / 0 °C

2: pyridine, DMAP / 48 h

3: 63 percent / CuCl, Et₃N / tetrahydrofuran / Heating

4: CuCl / tetrahydrofuran / 14 h / Heating

5: H₂ / 10percent Pd/C / ethanol; ethyl acetate / 4 h

With pyridine; dmap; hydrogen; triethylamine; copper(l) chloride; palladium on activated charcoal; In tetrahydrofuran; ethanol; ethyl acetate;

DOI:10.1021/jm970699s

Reference yield:

6-Chloro-3-methyl-hex-1-yn-3-ol → 3a-Methyl-1,2,3,3a,4,5-hexahydro-pyrrolo[1,2-a]quinoline (201541-31-3)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine, DMAP / 48 h

2: 63 percent / CuCl, Et₃N / tetrahydrofuran / Heating

3: CuCl / tetrahydrofuran / 14 h / Heating

4: H₂ / 10percent Pd/C / ethanol; ethyl acetate / 4 h

With pyridine; dmap; hydrogen; triethylamine; copper(l) chloride; palladium on activated charcoal; In tetrahydrofuran; ethanol; ethyl acetate;

DOI:10.1021/jm970699s

upstream raw materials:

3a-Methyl-1,2,3,3a-tetrahydro-pyrrolo[1,2-a]quinoline

5-chloro-2-pentanone

(R/S)-6-Chloro-3-methylhex-1-yn-3-yl acetate

(R/S)-2-Ethynyl-2-methyl-1-phenylpyrrolidine

Downstream raw materials:

3a-Methyl-1,2,3,3a,4,5-hexahydro-pyrrolo[1,2-a]quinolin-8-ylamine

Refernces