N-(2-amino-4-chlorophenyl)acetamide

Base Information

• Chemical Name: N-(2-amino-4-chlorophenyl)acetamide
• CAS No.: 51223-59-7
• Molecular Formula: C8H9ClN2O
• Molecular Weight: 184.625
• Hs Code.: 2924299090
• European Community (EC) Number: 801-945-9
• DSSTox Substance ID: DTXSID50481986
• Nikkaji Number: J29.394F
• Wikidata: Q82317810
• Mol file: 51223-59-7.mol

Synonyms:N-(2-amino-4-chlorophenyl)acetamide;51223-59-7;SCHEMBL9651918;DTXSID50481986;MFCD09043652;AKOS000102031;BS-38142;CS-0118142;EN300-59536;AJ-797/43492848;Z239120680

Chemical Property of N-(2-amino-4-chlorophenyl)acetamide

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 393.734°C at 760 mmHg
• Flash Point: 191.923°C
• PSA: 58.61000
• Density: 1.35g/cm³
• LogP: 3.11130
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 184.0403406
• Heavy Atom Count: 12
• Complexity: 174

Purity/Quality:

98%min ^*data from raw suppliers

N-(2-amino-4-chlorophenyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=C(C=C(C=C1)Cl)N

Technology Process of N-(2-amino-4-chlorophenyl)acetamide

There total 3 articles about N-(2-amino-4-chlorophenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

N-(4-chloro-2-nitrophenyl)-acetamide (881-51-6) → N-(2-amino-4-chlorophenyl)acetamide (51223-59-7)

Guidance literature:

With hydrazine hydrate; RaNi;

DOI:10.1007/BF00580557

Reference yield: 40.0%

N-(4-chlorophenyl)acetamide (539-03-7) → N-(2-amino-4-chlorophenyl)acetamide (51223-59-7)

Guidance literature:

With O-(4-nitrobenzoyl)hydroxylammonium trifluoromethanesulfonate; iron(II) bromide; silver(I) triflimide; In 2,2,2-trifluoroethanol; water; at 30 ℃; for 2h;

DOI:10.1002/chem.201605476

Reference yield:

→ N-(2-amino-4-chlorophenyl)acetamide (51223-59-7)

Guidance literature:

entspr. Phthaloylglycinanilid, N2H4;

DOI:10.1021/jo00898a038

upstream raw materials:

N-(4-chloro-2-nitrophenyl)-acetamide

N-(4-chlorophenyl)acetamide

Downstream raw materials:

acetic acid-(4-chloro-2-phenylazo-anilide)

1-(5-Chloro-2-mercapto-benzoimidazol-1-yl)-ethanone

5-chloro-1H-benzoimidazole-2-thiol

N-acetyl-N'-butyryl-4-chloro-1,2-phenylenediamine