2,4-DIFLUORO-3-FORMYLBENZONITRILE

Base Information

• Chemical Name: 2,4-DIFLUORO-3-FORMYLBENZONITRILE
• CAS No.: 149489-14-5
• Molecular Formula: C8H3F2NO
• Molecular Weight: 167.115
• Hs Code.: 2926909090
• Mol file: 149489-14-5.mol

Synonyms:2,4-DIFLUORO-3-FORMYLBENZONITRILE

Chemical Property of 2,4-DIFLUORO-3-FORMYLBENZONITRILE

Chemical Property:

• Boiling Point: 207.7±35.0 °C(Predicted)
• PSA: 40.86000
• Density: 1.35±0.1 g/cm3(Predicted)
• LogP: 1.64898

Purity/Quality:

97% ^*data from raw suppliers

2,4-Difluoro-3-formylbenzonitrile 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-DIFLUORO-3-FORMYLBENZONITRILE

There total 2 articles about 2,4-DIFLUORO-3-FORMYLBENZONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.33%

2,4-difluorobenzonitrile (3939-09-1,103496-86-2) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2,4-difluoro-3-formylbenzonitrile (149489-14-5)

Guidance literature:

2,4-difluorobenzonitrile; With lithium diisopropyl amide; In tetrahydrofuran; at -78 - -60 ℃; for 0.583333h; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; at -78 ℃; for 0.166667h;

Reference yield:

N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2,4-difluoro-3-formylbenzonitrile (149489-14-5)

Guidance literature:

With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at 0 ℃; for 0.333333h;

2,4-difluorobenzonitrile; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h;

N,N-dimethyl-formamide; With acetic acid; more than 3 stages;

Reference yield: 82.0%

2,4-difluoro-3-formylbenzonitrile (149489-14-5) → 2,4-difluoro-3-(hydroxymethyl)benzonitrile

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 0 ℃; for 1h;

upstream raw materials:

2,4-difluorobenzonitrile

N,N-dimethyl-formamide

Downstream raw materials:

(E)-3-(3-Cyano-2,6-difluoro-phenyl)-acrylic acid benzyl ester

2,4-Difluoro-3-(2-isocyanato-ethyl)-benzonitrile

3-(3-Aminomethyl-2,6-difluoro-phenyl)-propionic acid

3-(3-Cyano-2,6-difluoro-phenyl)-propionyl azide

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