BUTTPARK 11\03-70

Base Information

• Chemical Name: BUTTPARK 11\03-70
• CAS No.: 132766-74-6
• Molecular Formula: C₈H₇N₅O₂
• Molecular Weight: 205.176
• Hs Code.: 2933990090
• Mol file: 132766-74-6.mol

Synonyms:BUTTPARK 11\03-70;(5-Pyridin-2-yl-tetrazol-2-yl)-acetic acid

Chemical Property of BUTTPARK 11\03-70

Chemical Property:

• Boiling Point: 501.5±56.0 °C(Predicted)
• PKA: 2.78±0.10(Predicted)
• PSA: 93.79000
• Density: 1.59±0.1 g/cm3(Predicted)
• LogP: -0.18030

Purity/Quality:

98%min ^*data from raw suppliers

(5-Pyridin-2-yl-2H-tetrazol-2-yl)aceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BUTTPARK 11\03-70

There total 4 articles about BUTTPARK 11\03-70 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

ethyl 2-(5-(pyridine-2-yl)-2H-tetrazol-2-yl)acetate → 2-(5-(pyridin-2-yl)-2H-tetrazole-2-yl)acetic acid (132766-74-6)

Guidance literature:

With water; sodium hydroxide; In methanol; at 20 ℃; for 6h;

DOI:10.1007/s11243-016-0047-2

Reference yield:

2-Cyanopyridine (100-70-9,1232006-36-8) → 2-(5-(pyridin-2-yl)-2H-tetrazole-2-yl)acetic acid (132766-74-6)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium azide; lithium chloride; ammonium chloride / N,N-dimethyl-formamide / 10 h / Reflux

2: N,N-dimethyl-formamide / 80 h / 70 °C

3: water; sodium hydroxide / methanol / 6 h / 20 °C

With sodium azide; water; ammonium chloride; lithium chloride; sodium hydroxide; In methanol; N,N-dimethyl-formamide;

DOI:10.1007/s11243-016-0047-2

Reference yield:

5-(2-pyridyl)-1H-tetrazole (33893-89-9) → 2-(5-(pyridin-2-yl)-2H-tetrazole-2-yl)acetic acid (132766-74-6)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 80 h / 70 °C

2: water; sodium hydroxide / methanol / 6 h / 20 °C

With water; sodium hydroxide; In methanol; N,N-dimethyl-formamide;

DOI:10.1007/s11243-016-0047-2

upstream raw materials:

2-(2H-tetrazol-5-yl)-pyridine

bromoacetic acid

2-Cyanopyridine

5-(2-pyridyl)-1H-tetrazole