17α,21-Dihydroxypregn-4-ene-3,11,20-trione 21-phosphate

Base Information

Chemical Name:17α,21-Dihydroxypregn-4-ene-3,11,20-trione 21-phosphate
CAS No.:508-95-2
Molecular Formula:C₂₁H₂₉O₈P
Molecular Weight:440.43
Hs Code.:
Mol file:508-95-2.mol

Synonyms:17α,21-Dihydroxypregn-4-ene-3,11,20-trione 21-phosphate;21-Cortisonephosphoric acid;Cortisone phosphate

Suppliers and Price of 17α,21-Dihydroxypregn-4-ene-3,11,20-trione 21-phosphate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 17α,21-Dihydroxypregn-4-ene-3,11,20-trione 21-phosphate

Chemical Property:

Melting Point:194 - 198 °C
PSA：148.01000
LogP:2.10680

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of 17α,21-Dihydroxypregn-4-ene-3,11,20-trione 21-phosphate

There total 10 articles about 17α,21-Dihydroxypregn-4-ene-3,11,20-trione 21-phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 53-06-5
Cortisone

: 508-95-2
17-hydroxy-21-phosphonooxy-pregn-4-ene-3,11,20-trione

Guidance literature:: With pyridine; 2-cyanoethyl phosphate; dicyclohexyl-carbodiimide;
DOI:10.1021/jm00380a004

Reference yield:

: 5758-63-4
21-iodocortisone

: 508-95-2
17-hydroxy-21-phosphonooxy-pregn-4-ene-3,11,20-trione

Guidance literature:: With silver orthophosphate; phosphoric acid;

Reference yield:

: Sulfuric acid 2-((8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl ester p-tolyl ester

: 508-95-2
17-hydroxy-21-phosphonooxy-pregn-4-ene-3,11,20-trione

Guidance literature:: Multi-step reaction with 2 steps

1: NaI / acetone

2: 85 percent phosphoric acid, Et₃N / acetonitrile / 4 h / Heating

With phosphoric acid; triethylamine; sodium iodide; In acetone; acetonitrile;
DOI:10.1021/jm00380a004