3-METHYLADENINE

Base Information

Chemical Name:3-METHYLADENINE
CAS No.:5142-23-4
Molecular Formula:C6H7 N5
Molecular Weight:149.155
Hs Code.:2933990090
Mol file:5142-23-4.mol

Synonyms:Adenine,3-methyl- (7CI,8CI); 3-Methyl-6-aminopurine; 3-Methyladenine;6-Amino-3-methylpurine; N3-Methyladenine; NSC 66389

Suppliers and Price of 3-METHYLADENINE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
3-Methyladenine
50mg
$ 400.00

TRC
3-MethylAdenine
25mg
$ 55.00

TRC
3-MethylAdenine
250mg
$ 245.00

Tocris
3-Methyladenine ≥99%(HPLC)
50
$ 119.00

TCI Chemical
3-Methyladenine
1g
$ 419.00

TCI Chemical
3-Methyladenine
200mg
$ 120.00

SynQuest Laboratories
3-Methyladenine
10 mg
$ 29.00

Sigma-Aldrich
Autophagy Inhibitor, 3-MA
50mg
$ 118.00

Sigma-Aldrich
Autophagy Inhibitor, 3-MA
100mg
$ 129.00

Sigma-Aldrich
3-Methyladenine autophagy inhibitor
100mg
$ 184.00

Total 78 raw suppliers

Chemical Property of 3-METHYLADENINE

Chemical Property:

Vapor Pressure:0.0387mmHg at 25°C
Melting Point:~300 °C (dec.)(lit.)
Refractive Index:1.8070 (estimate)
Boiling Point:240.1oC at 760 mmHg
PKA:6.77±0.20(Predicted)
Flash Point:99oC
PSA：69.62000
Density:1.6g/cm3
LogP:0.52670
Storage Temp.:Store at +4°C
Solubility.:Soluble in DMSO (up to 3 mg/ml), or in DMF (up to 10 mg/ml).

Purity/Quality:

98% ^*data from raw suppliers

3-Methyladenine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22
Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Description Autophagy is a multi-step process that involves the degradation and digestion of intracellular components by the lysosome. This process allows cells to efficiently mobilize and recycle cellular constituents, and also prevents the accumulation of damaged organelles, misfolded proteins, and invading microorganisms. mTOR, whose activation is controlled by phosphoinositide 3-kinase (PI3K), is a key regulator of autophagy. 3-Methyladenine (3-MA) is a specific inhibitor of PI3K activity and one of the most widely used inhibitors of the initial phase of the autophagic process: the sequestering of cytoplasmic material by the lysosome. At 5 mM, 3-MA inhibits protein degradation in rat hepatocytes by 65%. 3-MA has been shown to block class I, class II, and class III PI3Ks, including some downstream targets, and to suppress the invasion of highly metastatic human fibrosarcoma HT1080 cells at 10 mM.
Uses 3-Methyladenine (3-MA) inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K). For use as an autophagy inhibitor, 3-MA is typically used at a concentration of 5 mM. A multi-use inhibitor that protects cerebellar granule cells from apoptosis. A synthetic intermediate and a cell-permeable autophagic sequestration blocker that protects cerebellar granule cells from apoptosis post serum/potassium deprivation

Technology Process of 3-METHYLADENINE

There total 29 articles about 3-METHYLADENINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%