5-BroMo-1H-indole-3-triMethyl ethanone

Base Information

• Chemical Name: 5-BroMo-1H-indole-3-triMethyl ethanone
• CAS No.: 32387-18-1
• Molecular Formula: C10H5BrF3NO
• Molecular Weight: 292.05
• Hs Code.: 2933998090
• Mol file: 32387-18-1.mol

Synonyms:5-BroMo-1H-indole-3-triMethyl ethanone;5-BroMo-1H-indole-3-trifluoroMethyl ethanone;5-Bromo-3-(trifluoroacetyl)indole;1-(5-bromo-1H-indol-3-yl)-2,2,2-trifluoroethanone

Chemical Property of 5-BroMo-1H-indole-3-triMethyl ethanone

Chemical Property:

• PSA: 32.86000
• LogP: 3.67540
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-3-(trifluoroacetyl)indole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BroMo-1H-indole-3-triMethyl ethanone

There total 2 articles about 5-BroMo-1H-indole-3-triMethyl ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

5-bromo-1H-indole (10075-50-0) + trifluoroacetic anhydride (407-25-0) → 1-(5-bromo-1H-indol-3-yl)-2,2,2-trifluoroethanone (32387-18-1)

Guidance literature:

In N,N-dimethyl-formamide; at 0 ℃; for 2.5h; Inert atmosphere;

Reference yield: 78.0%

→ 1-(5-bromo-1H-indol-3-yl)-2,2,2-trifluoroethanone (32387-18-1)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere;

Reference yield: 92.0%

1-(5-bromo-1H-indol-3-yl)-2,2,2-trifluoroethanone (32387-18-1) + phenylacetylene (536-74-3) → 2-(5-bromo-1H-indol-3-yl)-1,1,1-trifluoro-4-phenylbut-3-yn-2-ol (1417717-57-7)

Guidance literature:

phenylacetylene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

1-(5-bromo-1H-indol-3-yl)-2,2,2-trifluoroethanone; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 32h; Inert atmosphere;

DOI:10.1021/acs.orglett.0c02386

upstream raw materials:

5-bromo-1H-indole

trifluoroacetic anhydride

Downstream raw materials:

{3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5-bromo-indol-1-yl}acetic acid methyl ester

{3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5-cyano-indol-1-yl}acetic acid methyl ester

sodium {3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5-cyano-indol-1-yl}acetate

C₃₁H₃₃N₇O₃*ClH