(Z)-3-chloro-3-(3-fluorophenyl)acrylonitrile

Base Information

• Chemical Name: (Z)-3-chloro-3-(3-fluorophenyl)acrylonitrile
• CAS No.: 1192875-03-8
• Molecular Formula: C9H5ClFN
• Molecular Weight: 181.597
• Hs Code.: 2926907090
• Mol file: 1192875-03-8.mol

Synonyms:(Z)-3-chloro-3-(3-fluorophenyl)acrylonitrile

Chemical Property of (Z)-3-chloro-3-(3-fluorophenyl)acrylonitrile

Chemical Property:

• PSA: 23.79000
• LogP: 2.92898

Purity/Quality:

≥95% ^*data from raw suppliers

(Z)-3-Chloro-3-(3-fluorophenyl)acrylonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (Z)-3-chloro-3-(3-fluorophenyl)acrylonitrile

There total 5 articles about (Z)-3-chloro-3-(3-fluorophenyl)acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

3-(3-fluorophenyl)propiolonitrile → (Z)-3-chloro-3-(3'-fluorophenyl)acrylonitrile (1192875-03-8)

Guidance literature:

With palladium diacetate; lithium chloride; cyclo-octa-1,5-diene; In acetic acid; at 110 ℃; for 12h; stereoselective reaction;

DOI:10.1016/j.tetlet.2017.07.104

Reference yield: 86.0%

→ (Z)-3-chloro-3-(3'-fluorophenyl)acrylonitrile (1192875-03-8)

Guidance literature:

With palladium diacetate; acetic acid; lithium chloride; cyclo-octa-1,5-diene; at 110 ℃; for 12h;

Reference yield:

C9H7ClFNO → (Z)-3-chloro-3-(3'-fluorophenyl)acrylonitrile (1192875-03-8)

Guidance literature:

With water; at 39 - 41 ℃;

upstream raw materials:

1-(3-fluorophenyl)ethanone

Downstream raw materials:

(S)-3-{[3'-amino-5'-(3''-fluorophenyl)thiophene-2'-carbonyl]amino}piperidine-1-carboxylic acid tert-butyl ester

tert-butyl (3S)-3-({[5-(3-fluorophenyl)-3-{[(trichloroacetyl)carbamoyl]amino}thiophen-2-yl]carbonyl}amino)piperidine-1-carboxylate

Refernces

• 1、 Ball, Matthew,Jones, Martin F.,Kenley, Fiona,Pittam, J. David. "An Improved Convergent Synthesis of AZD7762: A One-Pot Construction of a Highly Substituted Thiophene at the Multikilogram Scale". . p. 310 - 316. Retrieved 2017/03/24.
• 2、 -. "METHODS OF PREPARING SUBSTITUTED HETEROCYCLES". Page/Page column 24-25. . Retrieved 2009/12/05.