4,5,6,7-tetrahydro-1-benzothiophene-3-carbaldehyde(SALTDATA: FREE)

Base Information

• Chemical Name: 4,5,6,7-tetrahydro-1-benzothiophene-3-carbaldehyde(SALTDATA: FREE)
• CAS No.: 851634-60-1
• Molecular Formula: C₉H₁₀OS
• Molecular Weight: 166.244
• Hs Code.: 2934999090
• Mol file: 851634-60-1.mol

Synonyms:4,5,6,7-tetrahydro-1-benzothiophene-3-carbaldehyde(SALTDATA: FREE);4,5,6,7-Tetrahydro-1-benzothiophene-3-carbaldehyde;MFCD12827456;4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbaldehyde

Chemical Property of 4,5,6,7-tetrahydro-1-benzothiophene-3-carbaldehyde(SALTDATA: FREE)

Chemical Property:

• PSA: 45.31000
• LogP: 2.43940

Purity/Quality:

97% ^*data from raw suppliers

4,5,6,7-Tetrahydro-1-benzothiophene-3-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,5,6,7-tetrahydro-1-benzothiophene-3-carbaldehyde(SALTDATA: FREE)

There total 4 articles about 4,5,6,7-tetrahydro-1-benzothiophene-3-carbaldehyde(SALTDATA: FREE) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(4,5,6,7-tetrahydrobenzo[b]thiophene-3-yl)methanol (851634-59-8) → 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbaldehyde (851634-60-1)

Guidance literature:

(4,5,6,7-tetrahydrobenzo[b]thiophene-3-yl)methanol; With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 0.333333h;

With sodium hydroxide; In diethyl ether; dichloromethane; water; for 0.25h;

Reference yield:

ethyl 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (14559-12-7) → 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbaldehyde (851634-60-1)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C

2: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / 1 h / -78 °C

With lithium aluminium tetrahydride; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; 2: |Swern Oxidation;

DOI:10.1007/s10593-015-1647-z

Reference yield:

ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (4506-71-2) → 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbaldehyde (851634-60-1)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride; sodium nitrite / 1,4-dioxane; water / 0.17 h / 0 - 5 °C

2: copper diacetate; ethanol / 1.5 h / 20 - 70 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C

4: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / 1 h / -78 °C

With hydrogenchloride; lithium aluminium tetrahydride; oxalyl dichloride; ethanol; copper diacetate; dimethyl sulfoxide; triethylamine; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 4: |Swern Oxidation;

DOI:10.1007/s10593-015-1647-z

upstream raw materials:

(4,5,6,7-tetrahydrobenzo[b]thiophene-3-yl)methanol

ethyl 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate