2-Acetyl-2,3,4,4a,11,12-hexahydro-12-methyl-14-oxo-1H-12a,5-(epoxymethano)pyrido[3',4':5,6]cyclohept[1,2-b]indole-5(6H)-carbaldehyde

Base Information

• Chemical Name: 2-Acetyl-2,3,4,4a,11,12-hexahydro-12-methyl-14-oxo-1H-12a,5-(epoxymethano)pyrido[3',4':5,6]cyclohept[1,2-b]indole-5(6H)-carbaldehyde
• CAS No.: 3329-93-9
• Molecular Formula: C21H22N2O4
• Molecular Weight: 366.41038
• Mol file: 3329-93-9.mol

Synonyms:2-Acetyl-2,3,4,4a,11,12-hexahydro-12-methyl-14-oxo-1H-12a,5-(epoxymethano)pyrido[3',4':5,6]cyclohept[1,2-b]indole-5(6H)-carbaldehyde

Chemical Property of 2-Acetyl-2,3,4,4a,11,12-hexahydro-12-methyl-14-oxo-1H-12a,5-(epoxymethano)pyrido[3',4':5,6]cyclohept[1,2-b]indole-5(6H)-carbaldehyde

Chemical Property:

• Melting Point: 300 - 302 °C
• PSA: 79.47000
• LogP: 1.89870

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 2-Acetyl-2,3,4,4a,11,12-hexahydro-12-methyl-14-oxo-1H-12a,5-(epoxymethano)pyrido[3',4':5,6]cyclohept[1,2-b]indole-5(6H)-carbaldehyde

There total 2 articles about 2-Acetyl-2,3,4,4a,11,12-hexahydro-12-methyl-14-oxo-1H-12a,5-(epoxymethano)pyrido[3',4':5,6]cyclohept[1,2-b]indole-5(6H)-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(19E)-17-hydroxy-3,7-seco-6-nor-cura-2(7),19-diene-16-carboxylic acid methyl ester (3368-87-4,56324-22-2,107657-44-3) → (5R)-2-acetyl-12ξ-methyl-14-oxo-(4ac)-2,3,4,4a,11,12-hexahydro-1H,6H-12ar,5c-oxaethano-pyrido[3',4':5,6]cyclohepta[1,2-b]indole-5-carbaldehyde (3329-93-9)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / CH₂Cl₂; benzene / Ambient temperature

2: CrO₃, Py / Ambient temperature

With pyridine; chromium(VI) oxide; potassium carbonate; In dichloromethane; benzene;

DOI:10.1002/hlca.19640470750

Reference yield:

(5R)-2-acetyl-5-hydroxymethyl-12ξ-methyl-(4ac)-2,3,4,4a,5,6,11,12-octahydro-1H-12ar,5c-oxaethano-pyrido[3',4':5,6]cyclohepta[1,2-b]indol-14-one (3329-92-8) → (5R)-2-acetyl-12ξ-methyl-14-oxo-(4ac)-2,3,4,4a,11,12-hexahydro-1H,6H-12ar,5c-oxaethano-pyrido[3',4':5,6]cyclohepta[1,2-b]indole-5-carbaldehyde (3329-93-9)

Guidance literature:

With pyridine; chromium(VI) oxide; Ambient temperature;

DOI:10.1002/hlca.19640470750

upstream raw materials:

(5R)-2-acetyl-5-hydroxymethyl-12ξ-methyl-(4ac)-2,3,4,4a,5,6,11,12-octahydro-1H-12ar,5c-oxaethano-pyrido[3',4':5,6]cyclohepta[1,2-b]indol-14-one

(19E)-17-hydroxy-3,7-seco-6-nor-cura-2⁽⁷⁾,19-diene-16-carboxylic acid methyl ester

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