Technology Process of biperiden hydrochloride
There total 4 articles about biperiden hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 6 steps
1.1: palladium dichloride; copper dichloride; oxygen / N,N-dimethyl-formamide; water / 3 h / 85 - 90 °C / 11400.8 - 12920.9 Torr / Autoclave
2.1: acetic acid / 3 h / 95 - 98 °C
3.1: sodium hydroxide / water; dichloromethane / pH 11 - 12
4.1: hydrogen bromide / acetone / 2 h / 0 - 5 °C / pH 2.8 - 3
5.1: sodium hydroxide / water; dichloromethane / 0 - 5 °C / pH 11 - 12
5.2: 1.67 h / -5 - 70 °C
6.1: hydrogenchloride / acetone / 0.33 h / 0 - 5 °C
With
hydrogenchloride; hydrogen bromide; oxygen; acetic acid; sodium hydroxide; copper dichloride; palladium dichloride;
In
dichloromethane; water; N,N-dimethyl-formamide; acetone;
2.1: |Mannich Aminomethylation / 5.2: |Grignard Reaction;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: acetic acid / 3 h / 95 - 98 °C
2.1: sodium hydroxide / water; dichloromethane / pH 11 - 12
3.1: hydrogen bromide / acetone / 2 h / 0 - 5 °C / pH 2.8 - 3
4.1: sodium hydroxide / water; dichloromethane / 0 - 5 °C / pH 11 - 12
4.2: 1.67 h / -5 - 70 °C
5.1: hydrogenchloride / acetone / 0.33 h / 0 - 5 °C
With
hydrogenchloride; hydrogen bromide; acetic acid; sodium hydroxide;
In
dichloromethane; water; acetone;
1.1: |Mannich Aminomethylation / 4.2: |Grignard Reaction;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrogen bromide / acetone / 2 h / 0 - 5 °C / pH 2.8 - 3
2.1: sodium hydroxide / water; dichloromethane / 0 - 5 °C / pH 11 - 12
2.2: 1.67 h / -5 - 70 °C
3.1: hydrogenchloride / acetone / 0.33 h / 0 - 5 °C
With
hydrogenchloride; hydrogen bromide; sodium hydroxide;
In
dichloromethane; water; acetone;
2.2: |Grignard Reaction;