2-(4-Aminophenoxy)aniline

Base Information

• Chemical Name: 2-(4-Aminophenoxy)aniline
• CAS No.: 30202-85-8
• Molecular Formula: C12H12N2O
• Molecular Weight: 200.24
• DSSTox Substance ID: DTXSID60519360
• Nikkaji Number: J60.193D
• Wikidata: Q82382473
• Mol file: 30202-85-8.mol

Synonyms:2-(4-Aminophenoxy)aniline;30202-85-8;4,2'-Oxybis(benzenamine);SCHEMBL510693;DTXSID60519360;LNLFBTIJJNGBQZ-UHFFFAOYSA-N;SB77712

Chemical Property of 2-(4-Aminophenoxy)aniline

Chemical Property:

• Melting Point: 76-77 °C
• Boiling Point: 357.9±27.0 °C(Predicted)
• PKA: 4.81±0.10(Predicted)
• PSA: 61.27000
• Density: 1.216±0.06 g/cm3(Predicted)
• LogP: 3.80570
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 200.094963011
• Heavy Atom Count: 15
• Complexity: 190

Purity/Quality:

99% ^*data from raw suppliers

2-(4-Aminophenoxy)aniline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)N)OC2=CC=C(C=C2)N

Technology Process of 2-(4-Aminophenoxy)aniline

There total 8 articles about 2-(4-Aminophenoxy)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

2-iodophenylamine (615-43-0) + 4-amino-phenol (123-30-8) → 2,4'-diaminodiphenyl ether (30202-85-8)

Guidance literature:

With 2-Picolinic acid; potassium phosphate; copper(l) iodide; In dimethyl sulfoxide; at 80 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ja9081815

Reference yield:

C16H16N2O3 → 2,4'-diaminodiphenyl ether (30202-85-8)

Guidance literature:

at 80 ℃; for 5h;

Reference yield:

2-(4-aminophenoxy)-1-nitrobenzene (26196-58-7) → 2,4'-diaminodiphenyl ether (30202-85-8)

Guidance literature:

With hydrazine hydrate; palladium 10% on activated carbon; In ethanol; water; Inert atmosphere;

DOI:10.1021/acs.jmedchem.1c00690

upstream raw materials:

2-(4-nitrophenoxy)benzenamine

potassium 2-nitrophenoxide

2-iodophenylamine

4-amino-phenol

Downstream raw materials:

2,4'-oxy-bis-phenyl isocyanate