N-(3-Chloro-2-hydroxypropyl)succinimide

Base Information

• Chemical Name: N-(3-Chloro-2-hydroxypropyl)succinimide
• CAS No.: 85834-37-3
• Molecular Formula: C₇H₁₀ClNO₃
• Molecular Weight: 191.614
• Hs Code.: 2925190090
• Mol file: 85834-37-3.mol

Synonyms:N-(3-Chloro-2-hydroxypropyl)succinimide

Chemical Property of N-(3-Chloro-2-hydroxypropyl)succinimide

Chemical Property:

• PSA: 57.61000
• LogP: -0.32700

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(3-Chloro-2-hydroxypropyl)succinimide

There total 2 articles about N-(3-Chloro-2-hydroxypropyl)succinimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

Succinimide (123-56-8,89963-74-6) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → 1-(3-chloro-2-hydroxypropyl)-2,5-pyrrolidinedione (85834-37-3)

Guidance literature:

With sodium methylate; In methanol; for 48h; Ambient temperature;

DOI:10.1002/jhet.5570200130

Reference yield: 42.36%

1-(2,3-epoxypropyl)-2,5-pyrrolidinedione (20958-21-8) → 1-(3-chloro-2-hydroxypropyl)-2,5-pyrrolidinedione (85834-37-3)

Guidance literature:

With hydrogenchloride; In chloroform; for 0.5h;

Reference yield:

1-(3-chloro-2-hydroxypropyl)-2,5-pyrrolidinedione (85834-37-3) → 1-[2-Oxo-3-(4-o-tolyl-piperazin-1-yl)-propyl]-pyrrolidine-2,5-dione

Guidance literature:

Multi-step reaction with 2 steps

1: 56 percent / CrO₃, 50percent aq. H₂SO₄ / acetone / 0 °C

2: 94 percent / triethylamine / acetonitrile / 1 h

With chromium(VI) oxide; sulfuric acid; triethylamine; In acetone; acetonitrile;

upstream raw materials:

1-(2,3-epoxypropyl)-2,5-pyrrolidinedione

Succinimide

epichlorohydrin

Refernces

• 1、 Mishra, Shri Krishna,Vani, T R,Rao, R Balaji. "Attempted synthesis of substituted 8-oxo-4-oxa-1-azabicyclooctane through intramolecular reductive cyclisation". . p. 641 - 644. Retrieved 2007/10/02.