4-(2-chloro-5H-pyrrolo[3,2-d]pyrimidin-4-yl)morpholine

Base Information

Chemical Name:4-(2-chloro-5H-pyrrolo[3,2-d]pyrimidin-4-yl)morpholine
CAS No.:114684-96-7
Molecular Formula:C₁₀H₁₁ClN₄O
Molecular Weight:238.677
Hs Code.:2934999090
DSSTox Substance ID:DTXSID50553218
Wikidata:Q82433756
Mol file:114684-96-7.mol

Synonyms:4-(2-chloro-5H-pyrrolo[3,2-d]pyrimidin-4-yl)morpholine;114684-96-7;4-{2-CHLORO-5H-PYRROLO[3,2-D]PYRIMIDIN-4-YL}MORPHOLINE;SCHEMBL16094377;DTXSID50553218;A894159;J-513286;2-Chloro-4-(morpholin-4-yl)-5H-pyrrolo[3,2-d]pyrimidine

Suppliers and Price of 4-(2-chloro-5H-pyrrolo[3,2-d]pyrimidin-4-yl)morpholine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-(2-Chloro-5H-pyrrolo[3,2-d]pyrimidin-4-yl)morpholine
50mg
$ 240.00

TRC
4-(2-Chloro-5H-pyrrolo[3,2-d]pyrimidin-4-yl)morpholine
10mg
$ 65.00

Crysdot
4-(2-Chloro-5H-pyrrolo[3,2-d]pyrimidin-4-yl)morpholine 95+%
250mg
$ 309.00

Crysdot
4-(2-Chloro-5H-pyrrolo[3,2-d]pyrimidin-4-yl)morpholine 95+%
1g
$ 772.00

Chemenu
4-(2-Chloro-5H-pyrrolo[3,2-d]pyrimidin-4-yl)morpholine 95%
1g
$ 729.00

American Custom Chemicals Corporation
4-(2-CHLORO-5H-PYRROLO[3,2-D]PYRIMIDIN-4-YL)MORPHOLINE 95.00%
5MG
$ 502.91

Total 11 raw suppliers

Chemical Property of 4-(2-chloro-5H-pyrrolo[3,2-d]pyrimidin-4-yl)morpholine

Chemical Property:

PSA：54.04000
LogP:1.51290
Storage Temp.:2-8°C
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:238.0621387
Heavy Atom Count:16
Complexity:249

Purity/Quality:

97% ^*data from raw suppliers

4-(2-Chloro-5H-pyrrolo[3,2-d]pyrimidin-4-yl)morpholine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1COCCN1C2=NC(=NC3=C2NC=C3)Cl

Technology Process of 4-(2-chloro-5H-pyrrolo[3,2-d]pyrimidin-4-yl)morpholine

There total 5 articles about 4-(2-chloro-5H-pyrrolo[3,2-d]pyrimidin-4-yl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16632-21-6
5-nitro-6-methyluracil

: 114684-96-7
2-Chloro-4-morpholin-4-yl-5H-pyrrolo[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1: 81.2 percent / dimethylformamide / 0.5 h / 130 - 135 °C

2: 82.46 percent / Zn, acetic acid / 1 h / 70 - 80 °C

3: 60.6 percent / POCl₃ / 6 h / Heating

4: 18 percent / POCl₃, diethylaniline / 40 h / Heating

5: potassium carbonate / aq. ethanol / 4 h / Heating

With potassium carbonate; acetic acid; N,N-diethylaniline; zinc; trichlorophosphate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1007/BF00758443

Reference yield:

: 65996-50-1
2,4-Dioxo-1,2,3,4-tetrahydropyrrolo<3,2-d>pyrimidine

: 114684-96-7
2-Chloro-4-morpholin-4-yl-5H-pyrrolo[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 60.6 percent / POCl₃ / 6 h / Heating

2: 18 percent / POCl₃, diethylaniline / 40 h / Heating

3: potassium carbonate / aq. ethanol / 4 h / Heating

With potassium carbonate; N,N-diethylaniline; trichlorophosphate; In ethanol;
DOI:10.1007/BF00758443

Reference yield:

: 116705-41-0,114684-92-3
5-Nitro-2,4-dioxo-6-(β-dimethylaminovinyl)-1,2,3,4-tetrahydropyrimidine

: 114684-96-7
2-Chloro-4-morpholin-4-yl-5H-pyrrolo[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: 82.46 percent / Zn, acetic acid / 1 h / 70 - 80 °C

2: 60.6 percent / POCl₃ / 6 h / Heating

3: 18 percent / POCl₃, diethylaniline / 40 h / Heating

4: potassium carbonate / aq. ethanol / 4 h / Heating

With potassium carbonate; acetic acid; N,N-diethylaniline; zinc; trichlorophosphate; In ethanol;
DOI:10.1007/BF00758443