indol-5-ylsulfonyl chloride

Base Information

• Chemical Name: indol-5-ylsulfonyl chloride
• CAS No.: 1094209-33-2
• Molecular Formula: C8H6ClNO2S
• Molecular Weight: 215.66
• Mol file: 1094209-33-2.mol

Synonyms:indol-5-ylsulfonyl chloride;1H‐indole‐5‐sulfonyl chloride

Chemical Property of indol-5-ylsulfonyl chloride

Chemical Property:

• PSA: 58.31000
• LogP: 3.17620

Purity/Quality:

97% ^*data from raw suppliers

1H-Indole-5-sulfonylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1H-Indole-5-sulfonyl Chloride is being used as a reagent in the preparation of sulphonamide derivatives of benzylamine for the treatment of CNS diseases.

Technology Process of indol-5-ylsulfonyl chloride

There total 1 articles about indol-5-ylsulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

5-bromo-1H-indole (10075-50-0) → 1H-indole-5-sulfonyl chloride (1094209-33-2)

Guidance literature:

5-bromo-1H-indole; With n-butyllithium; In diethyl ether; at -78 ℃; for 0.666667h;

With sulfur dioxide; In diethyl ether; at -78 - 20 ℃;

With N-chloro-succinimide; In diethyl ether; at 20 ℃; for 1.5h;

Reference yield: 32.0%

1-(3-chloro-5-(trifluoromethyl)phenyl)piperazine (346729-48-4) + 1H-indole-5-sulfonyl chloride (1094209-33-2) → 5-((4-(3-chloro-5-(trifluoromethyl)phenyl)piperazin-1-yl)sulfonyl)-1H-indole

Guidance literature:

With triethylamine; In 1,4-dioxane; at 25 - 60 ℃; for 20h; Inert atmosphere;

DOI:10.1016/j.bioorg.2020.104055

Reference yield: 28.0%

1H-indole-5-sulfonyl chloride (1094209-33-2) + N-(4-fluorophenyl)-1H-pyrazole-3-carboxamide (1236274-07-9) → 1-((1H-indol-5-yl)sulfonyl)-N-(4-fluorophenyl)-1H-pyrazole-3-carboxamide

Guidance literature:

With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;

upstream raw materials:

5-bromo-1H-indole